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| | [Orn5]-URP Basic information |
| Product Name: | [Orn5]-URP | | Synonyms: | [Orn5]-URP;L-Valine, L-alanyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-, cyclic (2→7)-disulfide;Ala-Cys-Phe-Trp-Orn-Tyr-Cys-Val（Disulfide bridge Cys2-Cys-7）;Orn5]-URP TFA;((4R,7S,10S,13S,16S,19R)-13-((1H-indol-3-yl)methyl)-19-((S)-2-aminopropanamido)-10-(3-aminopropyl)-16-benzyl-7-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-L-valine | | CAS: | 782485-03-4 | | MF: | C48H62N10O10S2 | | MW: | 1003.2 | | EINECS: | | | Product Categories: | | | Mol File: | 782485-03-4.mol | ![[Orn5]-URP Structure](CAS/20211123/GIF/782485-03-4.gif) |
| | [Orn5]-URP Chemical Properties |
| Boiling point | 1426.1±65.0 °C(Predicted) | | density | 1.40±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Powder | | pka | 3.60±0.10(Predicted) | | Water Solubility | Soluble to 1 mg/ml in water |
| | [Orn5]-URP Usage And Synthesis |
| Description | Urotensin-II (UT) receptor pure antagonist (pEC50= 7.24). Displays no agonist activity unlike other U-II/URP analogs. Inhibits the action of U-II in the rat aorta ring assay. | | Uses | [Orn5]-URP is a potent and selective pure antagonist of Urotensin-II receptor (UT), with an pEC50 of 7.24. [Orn5]-URP displays no agonist activity[1][2]. | | References | [1] Diallo M, et, al. [Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes. Peptides. 2008 May; 29(5): 813-9. DOI:10.1016/j.peptides.2007.10.023
[2] David C, et, al. Structure-activity relationships and structural conformation of a novel urotensin II-related peptide. Peptides. 2004 Oct; 25(10): 1819-30. DOI:10.1016/j.peptides.2004.04.019 |
| | [Orn5]-URP Preparation Products And Raw materials |
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