CytochroMe P450 14a-deMethylase inhibitor 1f

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Company Name: Shanghai civi chemical technology co.,Ltd  
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Email: sale@labgogo.com
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
CytochroMe P450 14a-deMethylase inhibitor 1f Basic information
Product Name:CytochroMe P450 14a-deMethylase inhibitor 1f
Synonyms:CytochroMe P450 14a-deMethylase inhibitor 1f;1H-1,2,4-Triazole-1-ethanol, α-[[[(3-chlorophenyl)methyl]-2-propen-1-ylamino]methyl]-α-(2,4-difluorophenyl)-;CYP51-IN-6
CAS:1155361-04-8
MF:C21H21ClF2N4O
MW:418.87
EINECS:
Product Categories:
Mol File:1155361-04-8.mol
CytochroMe P450 14a-deMethylase inhibitor 1f Structure
CytochroMe P450 14a-deMethylase inhibitor 1f Chemical Properties
Melting point 76.0-77.5 °C
Boiling point 576.618±60.00 °C(Press: 760.00 Torr)(predicted)
density 1.259±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka11.932±0.29(predicted)
Safety Information
MSDS Information
CytochroMe P450 14a-deMethylase inhibitor 1f Usage And Synthesis
UsesCYP51-IN-2 (compound 1f), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 15.6 ng/mL for Microsporum gypseum and Candida albicans, respectively[1].
References[1] Chai X, et, al. Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. Eur J Med Chem. 2009 May;44(5):1913-20. DOI:10.1016/j.ejmech.2008.11.007
CytochroMe P450 14a-deMethylase inhibitor 1f Preparation Products And Raw materials
Raw materials1H-1,2,4-Triazole-1-ethanol, α-(2,4-difluorophenyl)-α-[(2-propen-1-ylamino)methyl]-, hydrochloride (1:1)-->3-Chlorobenzyl bromide
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