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| | 15-deoxy-Δ12,14-Prostaglandin A1 Basic information |
| Product Name: | 15-deoxy-Δ12,14-Prostaglandin A1 | | Synonyms: | 15-deoxy-Δ12,14-Prostaglandin A1;15-deoxy-δ12,14-Prostaglandin A1;LDOCIRJMPUHXRM-YUJGFSRTSA-N;Prosta-10,12,14-trien-1-oic acid, 9-oxo-, (12Z,14E)-;15-deoxy-D12,14-Prostaglandin A1 | | CAS: | 573951-20-9 | | MF: | C20H30O3 | | MW: | 318.45 | | EINECS: | | | Product Categories: | | | Mol File: | 573951-20-9.mol |  |
| | 15-deoxy-Δ12,14-Prostaglandin A1 Chemical Properties |
| solubility | DMF: >75 mg/ml; DMSO: >50 mg/ml; Ethanol: >100 mg/ml; PBS (pH 7.2): >2.4 mg/ml |
| | 15-deoxy-Δ12,14-Prostaglandin A1 Usage And Synthesis |
| Description | 15-deoxy-Δ12,14-Prostaglandin A1 (15-deoxy-Δ12,14-PGA1) is a synthetic PGA1 analog. It shares common structural features with 15-deoxy-Δ12,14-PGJ2, which is a ligand for PPARγ. Antimitotic and antitumor activity have been reported for a similar analog, but there are no published reports on the biological activity of 15-deoxy-Δ12,14-PGA1 at this time. | | Uses | 15-Deoxy-Δ12,14-prostaglandin A1 is a deoxyanalog of prostaglandins that inhibits NF-κB signaling and induces apoptosis. 15-Deoxy-Δ12,14-prostaglandin A1 inhibits TNF-α-induced upregulation of inflammatory endothelial cell adhesion molecule (CAM) and avoids monocyte arrest[1]. | | Definition | ChEBI: 15d-PGA1 is a prostanoid. | | References | [1] Zernecke A, et al. Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction. FASEB J. 2003 Jun;17(9):1099-101. DOI:10.1096/fj.02-0485fje |
| | 15-deoxy-Δ12,14-Prostaglandin A1 Preparation Products And Raw materials |
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