2-chloro-3-fluoropyridin-4-aMine manufacturers
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| | 2-chloro-3-fluoropyridin-4-aMine Basic information |
| Product Name: | 2-chloro-3-fluoropyridin-4-aMine | | Synonyms: | 4-Amino-2-chloro-3-fluoropyridine;2-Chloro-3-fluoro-pyridin-4-ylamine;2-chloro-3-fluoropyridin-4-aMine;4-Pyridinamine, 2-chloro-3-fluoro-;2-Chloro-3-fluoro-4-pyridinamine | | CAS: | 1227577-03-8 | | MF: | C5H4ClFN2 | | MW: | 146.55 | | EINECS: | 818-063-5 | | Product Categories: | | | Mol File: | 1227577-03-8.mol |  |
| | 2-chloro-3-fluoropyridin-4-aMine Chemical Properties |
| Boiling point | 271.9±35.0 °C(Predicted) | | density | 1.449±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 2.81±0.42(Predicted) | | form | powder | | color | Brown | | InChI | InChI=1S/C5H4ClFN2/c6-5-4(7)3(8)1-2-9-5/h1-2H,(H2,8,9) | | InChIKey | VUGYOFOYGPXOFL-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=CC(N)=C1F |
| | 2-chloro-3-fluoropyridin-4-aMine Usage And Synthesis |
| Synthesis |
TFA (5 mL) was added to a solution of (2- chloro-3-fluoropyridin-4-yl)carbamic acid fert-butyl ester (1.9 g, 7.7 mmol) in DCM (10 mL). The solution was stirred at ambient temperature for 5 hours and concentrated under reduced pressure. The resultant residue was dissolved in DCM and purified by column chromatography on an NH2 cartridge (0-10 per cent MeOH in DCM) to afford 2-chloro-3-fluoropyridin-4-aMine as a beige solid (0.96 g, 94 per cent yield). NMR (400 MHz, CDC13): δ 7.82 (d, J = 5.4 Hz, 1H), 6.60 (t, J= 5.8 Hz, 1H), 4.38 (br s, 2H).
| | References | [1] Patent: WO2012/35039, 2012, A1. Location in patent: Page/Page column 97
[2] Patent: US2015/203455, 2015, A1. Location in patent: Paragraph 0461; 0463
[3] Patent: WO2015/110378, 2015, A1. Location in patent: Paragraph 00263; 00312
[4] Patent: US9440929, 2016, B2. Location in patent: Page/Page column 59; 60
[5] Patent: WO2017/12647, 2017, A1. Location in patent: Paragraph 0502 |
| | 2-chloro-3-fluoropyridin-4-aMine Preparation Products And Raw materials |
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