(3S,3'S)-4,4'-disulfanediylbis(3-aMinobutane-1-sulfonic acid)

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(3S,3'S)-4,4'-disulfanediylbis(3-aMinobutane-1-sulfonic acid) manufacturers

  • Firibastat
  • Firibastat pictures
  • $41.00
  • 2026-05-29
  • CAS:648927-86-0
  • Purity: 99.88%
  • Supply Ability: 10g
(3S,3'S)-4,4'-disulfanediylbis(3-aMinobutane-1-sulfonic acid) Basic information
Product Name:(3S,3'S)-4,4'-disulfanediylbis(3-aMinobutane-1-sulfonic acid)
Synonyms:(3S,3'S)-4,4'-disulfanediylbis(3-aMinobutane-1-sulfonic acid);Firibastat 648927-86-0;RB 150;1-Butanesulfonic acid, 4,4'-dithiobis[3-amino-, (3S,3'S)-;RB150 RB 150;Firibastat Impurity 1;hypertensive,inhibit,Inhibitor,angiotensin,Aminopeptidase,pressure,Firibastat,brain,blood;QGC-001
CAS:648927-86-0
MF:C8H20N2O6S4
MW:368.51
EINECS:
Product Categories:
Mol File:648927-86-0.mol
(3S,3'S)-4,4'-disulfanediylbis(3-aMinobutane-1-sulfonic acid) Structure
(3S,3'S)-4,4'-disulfanediylbis(3-aMinobutane-1-sulfonic acid) Chemical Properties
storage temp. Store at -20°C
solubility H2O: 2 mg/mL, clear (Warmed)
form Solid
color White to off-white
Water Solubility Water : 41.67 mg/mL (113.08 mM; ultrasonic and warming and heat to 60°C)
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
(3S,3'S)-4,4'-disulfanediylbis(3-aMinobutane-1-sulfonic acid) Usage And Synthesis
UsesFiribastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor (Ki=200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats[1][2].
Biological ActivityFiribast at (RB150; QGC001) is an orally active, blood-brain barrier-permeant prodrug composed of two molecules of disulfide-linked aminopeptidase A (APA; glutamyl aminopeptidase) active-site inhibitor EC33 (Ki = 300 nM) th at are released via the action of brain reductase in the brain. Firibast at exhibits antihypertensive efficacy in vivo (Blood pressure reduction ED50 = 30 mg/kg via p.o. in spontaneously hypertensive rats).
in vivo

When given orally, Firibastat (0.1-30 mg/kg; p.o.) crosses the gastrointestinal and blood-brain barriers, enters the brain, and generates two active molecules of EC33 which inhibit brain APA activity, blocking brain angiotensin III formation, and decrease blood pressure for several hours in hypertensive rats[2].

Animal Model:Normotensive and hypertensive DOCA-salt rats[1]
Dosage:0.1-30 mg/kg
Administration:P.o.
Result:Resulting in a dose-dependent decrease in mean arterial blood pressure (MABP).
References[1] Ferdinand KC, et al. Efficacy and Safety of Firibastat, A First-in-Class Brain Aminopeptidase A Inhibitor, in Hypertensive Overweight Patients of Multiple Ethnic Origins. Circulation. 2019;140(2):138-146. DOI:10.1161/CIRCULATIONAHA.119.040070
[2] Keck M, et al. Orally Active Aminopeptidase A Inhibitor Prodrugs: Current State and Future Directions. Curr Hypertens Rep. 2019;21(7):50. Published 2019 May 21. DOI:10.1007/s11906-019-0957-4
(3S,3'S)-4,4'-disulfanediylbis(3-aMinobutane-1-sulfonic acid) Preparation Products And Raw materials
Tag:(3S,3'S)-4,4'-disulfanediylbis(3-aMinobutane-1-sulfonic acid)(648927-86-0) Related Product Information
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