盐酸尼索西汀
| 中文名称 | 盐酸尼索西汀 |
|---|---|
| 中文同义词 | 盐酸尼索西汀;3-(2-甲氧基苯氧基)-N-甲基-3-苯基丙-1-胺盐酸盐;NISOXETINE HYDROCHLORIDE,NOREPINEPHRINE REUPTAKE (NET)抑制剂;Nisoxetine hydrochloride[N151];【进口分装现货】Nisoxetine hydrochloride盐酸尼索西汀57754-86-6;【进口分装现货】Nisoxetine hydrochloride盐酸尼索西汀57754-86-6 |
| 英文名称 | NISOXETINE HYDROCHLORIDE |
| 英文同义词 | LY-94,939;(+/-)-GAMMA-(2-METHOXYPHENOXY)-N-METHYL-BENZENEPROPANAMINE HYDROCHLORIDE;NISOXETINE HYDROCHLORIDE;NISOXETINE HYDROCHLORIDE (LY-94,939) NOR PINEPHRINE UPTAKE;(+/-)-g-(2-Methoxyphenoxy)-N-methylbenzenepropanaminehydrochloride;NisoxetineHCl;Nsc298819;(±)-γ-(2-methoxyphenoxy)-n-methyl-benzenepropanamine hydrochloride |
| CAS号 | 57754-86-6 |
| 分子式 | C17H22ClNO2 |
| 分子量 | 307.82 |
| EINECS号 | |
| 相关类别 | 其它;Adrenoceptor |
| Mol文件 | 57754-86-6.mol |
| 结构式 |  |
盐酸尼索西汀 性质
| 储存条件 | Sealed in dry,Room Temperature |
|---|---|
| 溶解度 | 在水中的溶解度20 mg/mL |
| 形态 | 固体 |
| 颜色 | 白色 |
| 水溶解性 | Soluble to 100 mM in water |
| InChI | InChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H |
| InChIKey | LCEURBZEQJZUPV-UHFFFAOYSA-N |
| SMILES | C(CCNC)(OC1=CC=CC=C1OC)C1C=CC=CC=1.Cl |
Kd: 0.76 nM (NET)
Nisoxetine inhibits [
3
H]Nisoxetine binding to rat frontal cortical membranes with a K
i
of 1.4±0.1 nM.
Nisoxetine inhibits [
3
H]Noradrenaline uptake into rat frontal cortical synaptosomes with a K
i
of 2.1±0.3 nM.
Nisoxetine inhibits Na
+
currents with IC
50
s of 1.6 and 28.6 µM at the membrane potential of -70 and -100 mV, respectively.
Nisoxetine (0.6-2.2 µM; a single intrathecal injection) displays dose-dependent effects on spinal anesthesia in rats.
Nisoxetine (2.2 µM; a single intrathecal injection) shows 100, 100, and 100% of blockades in motor function, proprioception, and with duration of action of about 61, 96, and 236 min, respectively.
| Animal Model: | Sprague-Dawley rats(290-340 g) |
| Dosage: | 0.6, 1.2, 1.8, 2.2 µM |
| Administration: | A single intrathecal injection |
| Result: | With ED 50 s of 0.82 , 0.75 and 0.70 µM in motor function, proprioception, and nociception respectively. |
安全信息
| 安全说明 | 22-26-36 |
|---|---|
| WGK Germany | 3 |
| RTECS号 | NI2922170 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-B1704A | 盐酸尼索西汀 Nisoxetine hydrochloride | 57754-86-6 | 1 mg | 300元 |
| 2025/12/22 | HY-B1704A | 盐酸尼索西汀 Nisoxetine hydrochloride | 57754-86-6 | 5mg | 800元 |