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| | 1-Methyl-1H-pyrazole-3-carboxamide Basic information |
| Product Name: | 1-Methyl-1H-pyrazole-3-carboxamide | | Synonyms: | 1-Methyl-1H-pyrazole-3-carboxamide;1-methyl-3-pyrazolecarboxamide;1-methylpyrazole-3-carboxamide;MFCD00464006;1-Methyl-1H-pyrazole-3-carboxylic acid amide;1H-Pyrazole-3-carboxamide, 1-methyl- | | CAS: | 89179-62-4 | | MF: | C5H7N3O | | MW: | 125.13 | | EINECS: | | | Product Categories: | | | Mol File: | 89179-62-4.mol |  |
| | 1-Methyl-1H-pyrazole-3-carboxamide Chemical Properties |
| Melting point | 139-141 °C | | Boiling point | 349.3±15.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 15.73±0.50(Predicted) | | Appearance | White to off-white Solid |
| | 1-Methyl-1H-pyrazole-3-carboxamide Usage And Synthesis |
| Synthesis | Step 3: To a solution of dichloromethane (50 mL) of the intermediate (6.0 g, 47.6 mmol) obtained in Step 2 was slowly added oxalyl chloride (6.12 mL, 71.4 mmol) and a catalytic amount of N,N-dimethylformamide (0.5 mL) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the resulting residue was redissolved in dichloromethane. Ammonia was passed into the solution for 30 min at 0°C. Subsequently, the reaction mixture was concentrated again under reduced pressure and the residue was suspended in tetrahydrofuran (50 mL) and filtered. The filtrate was concentrated under reduced pressure to afford the target product 1-methyl-1H-pyrazole-3-carboxamide (3.5 g, 59% yield).LC-MS (Method 3): m/z [M + H]+ = 126 (theoretical molecular weight = 125.13); retention time R = 0.76 min. | | References | [1] Patent: WO2015/22073, 2015, A1. Location in patent: Page/Page column 90; 91
[2] Patent: WO2014/139150, 2014, A1
[3] Patent: WO2014/150114, 2014, A1 |
| | 1-Methyl-1H-pyrazole-3-carboxamide Preparation Products And Raw materials |
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