5,5,5-Trifluoro-4-([((4-[(methoxycarbonyl)amino]phenyl)sulfonyl)amino]methyl)pentanoic acid

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5,5,5-Trifluoro-4-([((4-[(methoxycarbonyl)amino]phenyl)sulfonyl)amino]methyl)pentanoic acid Basic information
Product Name:5,5,5-Trifluoro-4-([((4-[(methoxycarbonyl)amino]phenyl)sulfonyl)amino]methyl)pentanoic acid
Synonyms:AKOS BBS-00001563;DC-SX029;5,5,5-Trifluoro-4-([((4-[(methoxycarbonyl)amino]phenyl)sulfonyl)amino]methyl)pentanoic acid
CAS:300713-88-6
MF:C14H17F3N2O6S
MW:398.35
EINECS:
Product Categories:
Mol File:Mol File
5,5,5-Trifluoro-4-([((4-[(methoxycarbonyl)amino]phenyl)sulfonyl)amino]methyl)pentanoic acid Structure
5,5,5-Trifluoro-4-([((4-[(methoxycarbonyl)amino]phenyl)sulfonyl)amino]methyl)pentanoic acid Chemical Properties
form Solid
color White to off-white
Safety Information
MSDS Information
5,5,5-Trifluoro-4-([((4-[(methoxycarbonyl)amino]phenyl)sulfonyl)amino]methyl)pentanoic acid Usage And Synthesis
UsesDC-SX029 is a potent SNX10 protein-protein interaction (PPI) inhibitor with oral activity with an estimated KD constant of ~0.935 μM by surface plasmon resonance (SPR). DC-SX029 blocks the SNX10-PIKfyve interaction, thereby decreased the TBK1/c-Rel signaling activation. DC-SX029 does not affect the protein level of SNX10. DC-SX029 has the potential for inflammatory bowel disease (IBD) research[1][2].
in vivo

DC-SX029 (1-6 mg/kg, orally, once a day for 10 days) can alleviate DSS-induced colitis in mice[1].

Animal Model:Mouse colitis model[1]
Dosage:1, 2, 6 mg/kg; daily; 10 days
Administration:Oral
Result:Restored the body weight of mice, reduced DAI during the recovery period, reduced the shortening of colon length, reduced the production of pro-inflammatory cytokines, and had a significant alleviation effect on erosion, inflammatory cell infiltration and crypt loss.
References[1] Weilian Bao, et al. Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation. Pharmacol Res. 2021 Jul:169:105679. DOI:10.1016/j.phrs.2021.105679
[2] Weilian Bao, et al. Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells. Sci Adv. 2023 Sep;9(35):eadh5016. DOI:10.1126/sciadv.adh5016
5,5,5-Trifluoro-4-([((4-[(methoxycarbonyl)amino]phenyl)sulfonyl)amino]methyl)pentanoic acid Preparation Products And Raw materials
Tag:5,5,5-Trifluoro-4-([((4-[(methoxycarbonyl)amino]phenyl)sulfonyl)amino]methyl)pentanoic acid(300713-88-6) Related Product Information
1-(4-Methoxycarbonylamino-benzenesulfonyl)-piperidine-4-carboxylic acid methyl N-[4-[3-[3-(trifluoromethyl)piperidine-1-carbonyl]piperidin-1-yl]sulfonylphenyl]carbamate Methyl N-[4-[[(2-cyclopropyl-2-hydroxypropyl)amino]sulfonyl]phenyl]carbamate 5,5,5-Trifluoro-4-([((4-[(methoxycarbonyl)amino]phenyl)sulfonyl)amino]methyl)pentanoic acid Sulfasalazine GYY 4137 Morpholine salt