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| | N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide dihydrochloride Basic information |
| | N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide dihydrochloride Chemical Properties |
| storage temp. | room temp | | solubility | H2O: soluble20mg/mL, clear | | form | powder | | color | white to beige | | Water Solubility | H2O: 20mg/mL, clear | | InChI | 1S/C19H23N3O.2ClH/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18;;/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23);2*1H | | InChIKey | KIGNSSHMCNBHQX-UHFFFAOYSA-N | | SMILES | Cl.Cl.N2(CCC(CC2)c3ncccc3)CC(=O)Nc1cc(ccc1)C |
| Hazard Codes | T | | Risk Statements | 25-36/37/38 | | Safety Statements | 26-45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide dihydrochloride Usage And Synthesis |
| Uses | N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide-d7 Dihydrochloride is labelled N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide Dihydrochloride (M320725) which acts as a selective agonist against dopamine D4 receptors, which affect cognitive performance and activity. | | Biological Activity | a 412997 dihydrochloride is a selective agonist of dopamine d4 receptor with ki values of 7.9 and 12.1 nm for human and rat d4 receptors, respectively [1].dopamine d4 receptor is a g protein-coupled receptor and is activated by dopamine. it plays an important role in cognition, parkinsons disease, addictive behaviors and so on.a 412997 dihydrochloride is a selective dopamine d4 receptor agonist. in calcium flux functional assays, a-412997 activated the rat dopamine d4 receptor with ec50 value and intrinsic activity of 28.4 nm and 0.83, respectively [1].in spontaneous hypertensive rat pups (shr pups), a 412997 significantly increased acquisition in the 5-trial repeated acquisition model. in the short-term social memory, a 412997 significantly shortened the second investigation time. in wistar rats and dawley rats, a 412997 (3 μm/kg, 10 μm/kg) increased locomotor activity [2]. in rats, a 412997 reduced non-rapid eye movement (nrem) sleep duration and increased waking duration. also, a 412997 reduced rapid eye movement (rem) sleep duration and delayed the onset of rem sleep [3]. | | storage | Desiccate at RT | | references | [1]. moreland rb, patel m, hsieh gc, et al. a-412997 is a selective dopamine d4 receptor agonist in rats. pharmacol biochem behav, 2005, 82(1): 140-147.
[2]. browman ke, curzon p, pan jb, et al. a-412997, a selective dopamine d4 agonist, improves cognitive performance in rats. pharmacol biochem behav, 2005, 82(1): 148-155.
[3]. nakazawa s, nakamichi k, imai h, et al. effect of dopamine d4 receptor agonists on sleep architecture in rats. prog neuropsychopharmacol biol psychiatry, 2015, 63: 6-13. |
| | N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide dihydrochloride Preparation Products And Raw materials |
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