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| | 2-Methyl-4-isothiazolin-3-one hydrochloride Basic information |
| | 2-Methyl-4-isothiazolin-3-one hydrochloride Chemical Properties |
| Melting point | 165-170° | | density | 1.551 at 21℃ | | vapor pressure | 0.777-1Pa at 20-25℃ | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White | | BRN | 3993054 | | Stability: | Hygroscopic | | Major Application | microbiology | | InChI | InChI=1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H | | InChIKey | SJXPQSRCFCPWQQ-UHFFFAOYSA-N | | SMILES | O=C1C=CSN1C.Cl | | LogP | -0.44 at 20℃ and pH2 | | Surface tension | 71.3mN/m at 1g/L and 20℃ | | CAS DataBase Reference | 26172-54-3(CAS DataBase Reference) | | EPA Substance Registry System | 3(2H)-Isothiazolone, 2-methyl-, hydrochloride (26172-54-3) |
| Hazard Codes | C | | Risk Statements | 34-42/43 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 1759 8/PG 2 | | WGK Germany | 3 | | TSCA | TSCA listed | | HazardClass | 8, 6.1 | | HS Code | 2934100090 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 3 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Dam. 1
Skin Corr. 1A
Skin Sens. 1 |
| | 2-Methyl-4-isothiazolin-3-one hydrochloride Usage And Synthesis |
| Uses | 2-Methyl-4-isothiazolin-3-one Hydrochloride is an isothiazolinone based biocide and preservative used in personal care products. It is also implicated as an allergen. It is also used for controlling microbial growth in water-containing solution. | | Application | Methylisothiazolinone (MIT) has been used:
as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death
to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites | | General Description | 2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a derivative of the synthetic isothiazolinone. | | Biochem/physiol Actions | 2-Methyl-4-isothiazolin-3-one hydrochloride (MIT) is a skin sensitizer known to cause contact dermatitis and allergy. It is extensively used in the cosmetic industry as a preservative. MIT is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth. | | storage | store at 2°C - 8°C,close container well. |
| | 2-Methyl-4-isothiazolin-3-one hydrochloride Preparation Products And Raw materials |
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