- Mal-PEG4-COOtBu
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2025-06-07
- CAS:518044-36-5
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Mal-PEG5-t-butly ester Basic information |
| Product Name: | Mal-PEG5-t-butly ester | | Synonyms: | Mal-PEG4-COOtBu;Mal-PEG5-t-butly ester;Mal-PEG4-t-butyl ester;MAL-dPEG4-t-butyl ester;MAL-PEG4-CH2CH2COOTBU;Mal-PEG4-OtBu;Mal-PEG4-Boc;4,7,10,13-Tetraoxapentadecanoic acid, 15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1,1-dimethylethyl ester | | CAS: | 518044-36-5 | | MF: | C19H31NO8 | | MW: | 401.45 | | EINECS: | | | Product Categories: | peg | | Mol File: | 518044-36-5.mol |  |
| | Mal-PEG5-t-butly ester Chemical Properties |
| Boiling point | 499.9±40.0 °C(Predicted) | | density | 1.156±0.06 g/cm3(Predicted) | | storage temp. | -20°C, stored under nitrogen | | solubility | DMSO : 100 mg/mL (249.10 mM; Need ultrasonic) | | pka | -2.34±0.20(Predicted) | | form | Oil | | color | Colorless to light yellow |
| | Mal-PEG5-t-butly ester Usage And Synthesis |
| Description | Mal-PEG4-t-butyl ester is a PEG linker containing a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. | | Uses | Mal-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Mal-PEG5-t-butly ester Preparation Products And Raw materials |
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