Mal-PEG1-NHS ester

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Mal-PEG1-NHS ester manufacturers

  • Mal-PEG1-NHS ester
  • Mal-PEG1-NHS ester pictures
  • 2025-06-07
  • CAS:1807518-72-4
  • Min. Order: 1g
  • Purity: >98.00%
  • Supply Ability: 1g
Mal-PEG1-NHS ester Basic information
Product Name:Mal-PEG1-NHS ester
Synonyms:Mal-PEG1-NHS ester;CAS_1807518-72-4;Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;Mal-PEG1-SPA;PROTAC,Antibody-drug conjugates linkers,Inhibitor,inhibit,PROTAC Linkers,Mal-PEG-1-NHS ester,PEG,Linker,ADC Linkers,Mal PEG1 NHS ester,ADC,MalPEG1NHS ester;Mal-PEG1-CH2CH2COONHS;2,5-dioxypyrolidine-1-yl3-(2-(2,5-dioxy-2,5-dihydro-1H-pyridine-1-yl)ethoxy)propanoic acidester;2,5-Dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate
CAS:1807518-72-4
MF:C13H14N2O7
MW:310.26
EINECS:
Product Categories:peg
Mol File:1807518-72-4.mol
Mal-PEG1-NHS ester Structure
Mal-PEG1-NHS ester Chemical Properties
Boiling point 488.4±55.0 °C(Predicted)
density 1.48±0.1 g/cm3(Predicted)
solubility Soluble in DCM
pka-2.35±0.20(Predicted)
form Solid
color White to off-white
InChIInChI=1S/C13H14N2O7/c16-9-1-2-10(17)14(9)6-8-21-7-5-13(20)22-15-11(18)3-4-12(15)19/h1-2H,3-8H2
InChIKeyAMRJPIJPLBUEHO-UHFFFAOYSA-N
SMILESC(ON1C(=O)CCC1=O)(=O)CCOCCN1C(=O)C=CC1=O
Safety Information
MSDS Information
Mal-PEG1-NHS ester Usage And Synthesis
DescriptionMal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Biological ActivityMal-PEG1-NHS ester is a cleavable PEG-based ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Mal-PEG1-NHS ester Preparation Products And Raw materials
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