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| | Amino-PEG8-t-Boc-Hydrazide Basic information |
| Product Name: | Amino-PEG8-t-Boc-Hydrazide | | Synonyms: | Amino-PEG8-t-Boc-Hydrazide;Amino-PEG8- Boc-Hydrazide;NH2-PEG8-HZ-Boc;H2N-PEG8-CH2CH2CONHNHBoc;Amino-PEG8-hydrazide-Boc;Hydrazinecarboxylic acid, 2-(27-amino-1-oxo-4,7,10,13,16,19,22,25-octaoxaheptacos-1-yl)-, 1,1-dimethylethyl ester;tert-Butyl 30-amino-4-oxo-7,10,13,16,19,22,25,28-octaoxa-2,3-diazatriacontan-1-oate;Amino-PEG8-N-Boc-hydrazide | | CAS: | 1334169-96-8 | | MF: | C24H49N3O11 | | MW: | 555.66 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1334169-96-8.mol |  |
| | Amino-PEG8-t-Boc-Hydrazide Chemical Properties |
| density | 1.116±0.06 g/cm3(Predicted) | | pka | 8.99±0.43(Predicted) |
| | Amino-PEG8-t-Boc-Hydrazide Usage And Synthesis |
| Description | Amino-PEG8-t-Boc-hydrazide is a crosslinker containing an amino group and a Boc-protected hydrazide. The hydrophilic PEG spacer increases solubility in aqueous media. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc can be deprotected under mild acidic conditions to form a reactive hydrazide, which can then be coupled with various carbonyl groups. | | Uses | Amino-PEG8-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Amino-PEG8-t-Boc-Hydrazide Preparation Products And Raw materials |
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