Azido-PEG2-t-Boc-hydrazide manufacturers
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| | Azido-PEG2-t-Boc-hydrazide Basic information |
| Product Name: | Azido-PEG2-t-Boc-hydrazide | | Synonyms: | tert-butyl N-[3-[2-(2-azidoethoxy)ethoxy]propanoylamino]carbamate;Azido-PEG2-t-Boc-hydrazide;Azido-PEG2-hydrazide-Boc;Azido-PEG2-Boc-Hydrazide;N3-PEG2-hydrazide-Boc;tert-butyl 2-(3-(2-(2-azidoethoxy)ethoxy)propanoyl)hydrazine-1-carboxylate | | CAS: | 2100306-56-5 | | MF: | C12H23N5O5 | | MW: | 317.35 | | EINECS: | | | Product Categories: | | | Mol File: | 2100306-56-5.mol |  |
| | Azido-PEG2-t-Boc-hydrazide Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | form | Viscous Liquid | | color | Colorless to light yellow |
| | Azido-PEG2-t-Boc-hydrazide Usage And Synthesis |
| Description | Azido-PEG2-t-Boc-hydrazide is a PEG linker containing an azide group and a Boc-protected hydrazide. The azide group allows the reaction with with alkyne, BCN, DBCO via Click Chemistry. The Boc can be deprotected under mild acidic conditions to form a reactive hydrazide, which can then be coupled with various carbonyl groups. | | Uses | Azido-PEG2-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-hydrazide-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azido-PEG2-t-Boc-hydrazide Preparation Products And Raw materials |
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