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| | m-PEG7-aldehyde Basic information |
| Product Name: | m-PEG7-aldehyde | | Synonyms: | m-PEG7-aldehyde;MPEG7-ALD;mPEG7-CHO;m-PEG9-aldehyde;MPEG7-CH2CH2CHO;mPEG7-pAld;m-PEG6-CH2CH2CHO;4,7,10,13,16,19,22-Heptaoxatricosanal | | CAS: | 1058691-77-2 | | MF: | C16H32O8 | | MW: | 352.42 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1058691-77-2.mol |  |
| | m-PEG7-aldehyde Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | solubility | Soluble in Water, DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | m-PEG7-aldehyde Usage And Synthesis |
| Description | m-PEG7-aldehyde is a PEG reagent containing an aldehyde group. Aldehyde can react with hydrazide and aminooxy groups for labeling and crosslinking carbonyls. | | Biological Activity | M-PEG7-aldehyde is a non-cleavable ADC linker for antibody drug conjugate (ADC) synthesis,it is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis. | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | | target | | Non-cleavable < span> | PEGs | |
| | m-PEG7-aldehyde Preparation Products And Raw materials |
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