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| | tert-butyl 4-amino-1H-pyrazole-1-carboxylate Basic information |
| Product Name: | tert-butyl 4-amino-1H-pyrazole-1-carboxylate | | Synonyms: | tert-butyl 4-amino-1H-pyrazole-1-carboxylate;tert-butyl 4-aminopyrazole-1-carboxylate;4-amino-pyrazole-1-carboxylic acid tert-butyl ester;1H-Pyrazole-1-carboxylic acid, 4-amino-, 1,1-dimethylethyl ester;1-Boc-4-aminopyrazole;tert-Butyl 4-amino-1H-pyrazol-1-carboxylate;tert-butyl 4-amino-1H-pyrazole-1-carboxylate - [B81113] | | CAS: | 1018446-95-1 | | MF: | C8H13N3O2 | | MW: | 183.21 | | EINECS: | | | Product Categories: | | | Mol File: | 1018446-95-1.mol |  |
| | tert-butyl 4-amino-1H-pyrazole-1-carboxylate Chemical Properties |
| Boiling point | 306.7±34.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 2.36±0.11(Predicted) | | Appearance | Brown to reddish brown Solid |
| | tert-butyl 4-amino-1H-pyrazole-1-carboxylate Usage And Synthesis |
| Synthesis | (c) Synthesis of tert-butyl 4-amino-1H-pyrazole-1-carboxylate (A55): tert-butyl 4-nitro-1H-pyrazole-1-carboxylate (A54, 3.70 g, 17.4 mmol) and 10% Pd/C (0.300 g) were suspended in EtOH (150 mL) and moistened with ~5% water. The reaction mixture was stirred for 20 h at room temperature under hydrogen (1 atm) atmosphere. Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with EtOAc (about 100 mL). The filtrate was concentrated under reduced pressure to afford tert-butyl 4-amino-1H-pyrazole-1-carboxylate (3.09 g, 97% yield) as a light brown solid.1H NMR (400 MHz, CDCl3) δ 7.54 (d, J = 0.6 Hz, 1H), 7.40 (d, J = 0.8 Hz, 1H), 3.10 (s, 2H), 1.62 (s, 9H). LCMS analysis: retention time (rt) 3.75 min; no product ions detected. | | References | [1] Patent: WO2014/128465, 2014, A1. Location in patent: Page/Page column 79
[2] Patent: WO2008/139161, 2008, A1. Location in patent: Page/Page column 197
[3] Patent: WO2015/89337, 2015, A1. Location in patent: Paragraph 0211
[4] Patent: WO2015/25197, 2015, A1. Location in patent: Paragraph 000128
[5] Patent: US2009/325956, 2009, A1. Location in patent: Page/Page column 38 |
| | tert-butyl 4-amino-1H-pyrazole-1-carboxylate Preparation Products And Raw materials |
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