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| | (2-Bromobenzyl)methylamine Basic information |
| Product Name: | (2-Bromobenzyl)methylamine | | Synonyms: | (2-Bromobenzyl)methylamine95%;N-Methyl-2-bromobenzylamine;2-Bromo-N-methyl-Benzenemethanamine;(2-BROMOBENZYL)METHY;2-Bromo-N-methylbenzylamine 97%;Benzenemethanamine, 2-bromo-N-methyl-;SKL295;2-Bromo-N-methylbenzylamine | | CAS: | 698-19-1 | | MF: | C8H10BrN | | MW: | 200.08 | | EINECS: | | | Product Categories: | Polyamines | | Mol File: | 698-19-1.mol |  |
| | (2-Bromobenzyl)methylamine Chemical Properties |
| Boiling point | 71-74 °C2 mm Hg(lit.) | | density | 1.358 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.5670(lit.) | | Fp | 220 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Viscous Liquid | | pka | 9.14±0.10(Predicted) | | Appearance | Colorless to light yellow Liquid | | Sensitive | Air Sensitive | | InChI | 1S/C8H10BrN/c1-10-6-7-4-2-3-5-8(7)9/h2-5,10H,6H2,1H3 | | InChIKey | TUADRPBKJHMHDH-UHFFFAOYSA-N | | SMILES | CNCc1ccccc1Br |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 2 | | HazardClass | 8 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Chronic 3 |
| | (2-Bromobenzyl)methylamine Usage And Synthesis |
| Synthesis | Preparation of Example (Compound 22a): 29.4 g of o-bromobenzaldehyde and 81 mL of 40% aqueous methylamine were mixed with 238 mL of tetrahydrofuran (THF). At room temperature, 19 g of sodium borohydride (NaBH4) was added in batches over 25 minutes. The reaction mixture was stirred overnight at room temperature and then concentrated using a rotary evaporator. The residue was stirred into ice water and the aqueous phase was extracted twice with ether. The combined ether phases were concentrated by evaporation under reduced pressure. The product was purified by silica gel column chromatography using ethyl acetate or ethyl acetate/methanol (4:1) as eluent to give 18.5 g of N-methyl-2-bromobenzylamine (22a) in yellow liquid form. Yield: 58%. | | References | [1] Patent: US6232468, 2001, B1
[2] Tetrahedron, 2003, vol. 59, # 40, p. 8049 - 8056 |
| | (2-Bromobenzyl)methylamine Preparation Products And Raw materials |
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