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| | 2-Chloro-4-cyanophenylboronic Acid Pinacol Ester Basic information |
| Product Name: | 2-Chloro-4-cyanophenylboronic Acid Pinacol Ester | | Synonyms: | 2-Chloro-4-cyanophenylboronic Acid Pinacol Ester;3-chloro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile;2-(2-chloro-4-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;Benzonitrile, 3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-carbonitrile;2-Chloro-4-cyanobenzeneboronic acid pinacol ester | | CAS: | 945391-06-0 | | MF: | C13H15BClNO2 | | MW: | 263.53 | | EINECS: | | | Product Categories: | | | Mol File: | 945391-06-0.mol |  |
| | 2-Chloro-4-cyanophenylboronic Acid Pinacol Ester Chemical Properties |
| Melting point | 137.6-143.2 °C | | Boiling point | 362.8±32.0 °C(Predicted) | | density | 1.16±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to light yellow Solid |
| | 2-Chloro-4-cyanophenylboronic Acid Pinacol Ester Usage And Synthesis |
| Synthesis | Bis(pinacolato)diboron (391 mg, 1.54 mmol), potassium acetate (412 mg, 4.5 mmol) and [1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloride (102 mg, 0.14 mmol) were sequentially added to the reaction flask under nitrogen atmosphere. A solution of 2-chloro-4-bromobenzonitrile (300 mg, 1.4 mmol) in dioxane (15 mL) was then added. The reaction mixture was stirred at 80 °C for 12 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered through diatomaceous earth and the filter cake was washed with ethyl acetate (50 mL). The filtrate was concentrated under reduced pressure and the resulting residue was purified by preparative thin layer chromatography on silica gel to afford the white solid product 3-chloro-4-pinacolboronate benzonitrile (73 mg, 20% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 7.78 (d, J = 7.6 Hz, 1H), 7.62 (d, J = 1.2 Hz, 1H), 7.52 (dd, J = 7.6 Hz, 1.2 Hz, 1H), 1.37 (s, 12H) ppm. | | References | [1] Patent: EP3275867, 2018, A1. Location in patent: Paragraph 0206; 0207 |
| | 2-Chloro-4-cyanophenylboronic Acid Pinacol Ester Preparation Products And Raw materials |
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