GSK106 (hydrochloride)

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GSK106 (hydrochloride) Basic information
Product Name:GSK106 (hydrochloride)
Synonyms:GSK106 (hydrochloride);(3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone Hydrochloride;GSK106;(4-(1-methyl-2-(1-ethylindolin-3-yl)-1H-benzo[d]imidazole-6-carbonyl)piperidin-3-amine hydrochloride
CAS:1652591-82-6
MF:C24H28ClN5O
MW:437.965
EINECS:
Product Categories:
Mol File:1652591-82-6.mol
GSK106 (hydrochloride) Structure
GSK106 (hydrochloride) Chemical Properties
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form A crystalline solid
color Off-white to light yellow
Safety Information
MSDS Information
GSK106 (hydrochloride) Usage And Synthesis
DescriptionProtein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK106 is an inactive control for the selective PAD4 inhibitors, GSK484 and GSK199 . It does not inhibit PAD4 nor does it prevent the citrullination of PAD4 target proteins or the formation of neutrophil extracellular traps in mouse or human neutrophils (IC50s > 100 μM). See the Structural Genomics Consortium (SGC) website for more information on both GSK484 and GSK106.
Uses(3-Amino-1-piperidinyl)[2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzimidazol-6-yl]-methanone Hydrochloride is structurally similar to (3-Amino-1-piperidinyl)[1-methyl-2-(1-methyl-1H-indol-2-yl)-1H-benzimidazol-5-yl]-methanone TFA Salt (G797395) and is suitable to use as a control to identify inhibitors for protein arginine deiminase 4 (PAD4).
GSK106 (hydrochloride) Preparation Products And Raw materials
Tag:GSK106 (hydrochloride)(1652591-82-6) Related Product Information
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