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BOC Sciences |
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inquiry@bocsci.com |
| Company Name: |
InvivoChem |
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+1-708-310-1919 +1-13798911105 |
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| | Forodesine Basic information |
| Product Name: | Forodesine | | Synonyms: | Burixafor hydrobromide (Synonyms: TG-0054 hydrobromide);Burixafor hydrobromide (TG-0054 hydrobromide);TG-0054 hydrobromide;Burixafor HBr | | CAS: | 1191450-19-7 | | MF: | C27H52BrN8O3P | | MW: | 647.64 | | EINECS: | | | Product Categories: | | | Mol File: | 1191450-19-7.mol |  |
| | Forodesine Chemical Properties |
| storage temp. | Store at -20°C | | form | Solid | | color | Light yellow to yellow | | Water Solubility | Water : 50 mg/mL |
| | Forodesine Usage And Synthesis |
| Description | Burixafor, also known as TG-0054, is an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. Burixafor binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation; this may the mobilization of hematopoietic stem and progenitor cells from the bone marrow into blood. Note: Elemental analysis showed it was a salt with 3 HBr and 3 water. | | Uses | Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist of CXCR4 and a well anti-angiogenic drug that is of potential value in treating choroid neovascularization[1]. Burixafor hydrobromide (TG-0054 hydrobromide) mobilizes mesenchymal stem cells, attenuates inflammation, and preserves cardiac systolic function in a porcine model of myocardial infarction[2]. | | IC 50 | CXCR4 | | References | [1] Shelke NB, et al. Intravitreal Poly(L-lactide) Microparticles Sustain Retinal and Choroidal Delivery of TG-0054, a Hydrophilic Drug Intended for Neovascular Diseases. Drug Deliv Transl Res. 2011 Feb;1(1):76-90. DOI:10.1007/s13346-010-0009-8
[2] Hsu WT, et al. CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction. Cell Transplant. 2015;24(7):1313-28. DOI:10.3727/096368914X681739 |
| | Forodesine Preparation Products And Raw materials |
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