化合物 THIOFLOSULIDE
| 中文名称 | 化合物 THIOFLOSULIDE |
|---|---|
| 中文同义词 | 化合物 T15687;化合物 THIOFLOSULIDE |
| 英文名称 | L-745337 |
| 英文同义词 | L-745337;Thioflosulide;Methanesulfonamide, N-[6-[(2,4-difluorophenyl)thio]-2,3-dihydro-1-oxo-1H-inden-5-yl]- |
| CAS号 | 158205-05-1 |
| 分子式 | C16H13F2NO3S2 |
| 分子量 | 369.41 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 158205-05-1.mol |
| 结构式 |  |
化合物 THIOFLOSULIDE 性质
| 沸点 | 495.8±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.52±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 6+-.0.20(Predicted) |
Thioflosulide (L-745337) 是一种选择性的 COX2 抑制剂，IC50 值为 2.3 nM，具有抗炎功效。
|
COX-2 2.3 nM (IC 50 ) |
In a rat model of postoperative pain, Thioflosulide (L-745337) (40-80 μg, intrathecal) coadministered with intrathecal morphine (0.5 nmol) increases the withdrawal thresholds in a dose-dependent manner. Adding 80 μg Thioflosulide (L-745337) to 1 nmol morphine produces an antiallodynic effect greater than that of morphine at twice the dose. Thioflosulide (L-745337) (0-30 mg/kg, s.c.) combined with intrathecal morphine results in the same antiallodynic response as morphine alone. Thioflosulide (L-745337) shows anti-inflammatory activity, with the effective-dose of 0.4 mg/kg, and the maximal anti-inflammation dose of 5 mg/kg in arthritic rats.