ChemicalBook > Product Catalog >API >Antineoplastic agents >Antimetabolites, Antineoplastic >L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2)

L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2)

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L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2) Suppliers list
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Products Intro: Product Name:Lometrexol disodium
CAS:120408-07-3
Purity:>=98.0% Package:$275.9/1mg;$830.9/5mg;$1395.9/10mg;Bulk package Remarks:98.0%
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Products Intro: Product Name:Lometrexol disodium
CAS:120408-07-3
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Company Name: Biosynth Biological Technology (Suzhou) Co Ltd  
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Products Intro: Product Name:Lometrexol disodium
CAS:120408-07-3
Company Name: Adooq Bioscience LLC  
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Products Intro: Product Name:Lometrexol disodium
CAS:120408-07-3
Company Name: BOC Sciences  
Tel: 16314854226
Email: info@bocsci.com
Products Intro: Product Name:Lometrexol disodium
CAS:120408-07-3
Purity:98%
L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2) Basic information
Product Name:L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2)
Synonyms:L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2);Lometrexol disodium
CAS:120408-07-3
MF:C21H26N5NaO6
MW:467.46
EINECS:
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Mol File:120408-07-3.mol
L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2) Structure
L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2) Chemical Properties
storage temp. Store at -20°C
solubility DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM)
form Solid
color White to light yellow
Safety Information
MSDS Information
L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2) Usage And Synthesis
UsesAntineo plastic.
in vivo

Lometrexol (DDATHF; i.p.; 15-60 mg/kg; on gestation day 7.5) disodium induces neural tube defects (NTDs) by disturbing purine metabolism and increases the rate of embryonic resorption and growth retardation in a dose-dependent manner[1].
Lometrexol (i.p.; 40 mg/kg; on gestation day 7.5) disodium decreases glycinamide ribonucleotide formyl transferase (GARFT) activity and Changes of ATP, GTP, dATP and dGTP levels[1].
Lometrexol (i.p.; 40 mg/kg; on gestation day 7.5) disodium induces abnormal proliferation and apoptosis exist in neural tube defects (NTDs)[1].

Animal Model:C57BL/6 mice (7-8 week, 18-20 g)[1]
Dosage:15, 30, 35, 40, 45 and 60 mg/kg
Administration:Intraperitoneal injection; on gestation day 7.5
Result:Increased the rate of embryonic resorption and growth retardation in a dose-dependent manner.
Animal Model:C57BL/6 mice (7-8 week, 18-20 g)[1]
Dosage:40 mg/kg
Administration:Intraperitoneal injection; on gestation day 7.5, for 0, 6, 24, 48 and 96 hours
Result:Inhibited glycinamide ribonucleotide formyl transferase (GARFT) activity and GARFT activity was maximally inhibited after at 6 hours.
Decreased the levels of ATP, GTP, dATP, and dGTP of NTDs embryonic brain tissue significantly at 6 hours.
Animal Model:C57BL/6 mice (7-8 week, 18-20 g)[1]
Dosage:40 mg/kg
Administration:Intraperitoneal injection; on gestation day 7.5, for 4 days
Result:Decreased the expression of proliferation-related genes (Pcna, Foxg1 and Ptch1) and increased the expression of apoptosis-related genes (Bax, Casp8 and Casp9) in NTD groups.
L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2) Preparation Products And Raw materials
Tag:L-Glutamic acid,N-[4-[2-[(6R)-2-amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]-,sodium salt (1:2)(120408-07-3) Related Product Information
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