3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride

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3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride manufacturers

  • Roxindole
  • Roxindole pictures
  • $293.00
  • 2026-07-27
  • CAS:112192-04-8
  • Purity: 98.93%
  • Supply Ability: 10g
3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride Basic information
Product Name:3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride
Synonyms:ROXINDOLE HYDROCHLORIDE;RoxindoleHCl;3-[4-(3,6-Dihydro-4-phenylpyridine-1(2H)-yl)butyl]-1H-indole-5-ol;3-[4-[(3,6-Dihydro-4-phenylpyridin)-1(2H)-yl]butyl]-1H-indol-5-ol;Roxindole [inn];1H-Indol-5-ol, 3-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-;Roxindole;3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride
CAS:112192-04-8
MF:C23H26N2O
MW:346.47
EINECS:
Product Categories:Dopamine receptor
Mol File:112192-04-8.mol
3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride Structure
3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride Chemical Properties
Melting point >165°C (dec.)
Boiling point 575.7±50.0 °C(Predicted)
density 1.173±0.06 g/cm3(Predicted)
storage temp. Desiccate at -20°C
solubility DMSO (Slightly), Water (Slightly)
pka10.15±0.40(Predicted)
form Solid
color Pale Beige to Light Beige
Stability:Hygroscopic
Safety Information
MSDS Information
3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride Usage And Synthesis
UsesRoxindole Hydrochloride is a selective and potent presynaptic D-2 dopamine autoreceptor agonist.
DefinitionChEBI: Roxindole is a member of indoles. It has a role as an alpha-adrenergic antagonist and a serotonergic drug.
Biological ActivityDopamine D 2 autoreceptor agonist, with affinity for D 3 , D 4 and 5-HT 1 receptors (pK i values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D 2 , D 3 , D 4 , 5-HT 1A , 5-HT 1B and 5-HT 1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo .
in vivo

Roxindole inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.)[1].
Roxindole (EMD 49980) (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH-DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g)[3].

3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride Preparation Products And Raw materials
Tag:3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride(112192-04-8) Related Product Information
3-(4-(4-Phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl)indole, HCl 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Roxindole mesylate 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride 1,2,3,6-Tetrahydro-4-phenyl-pyridine 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride