- TRIMETHYL CITRATE
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- $100.00
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2026-09-11
- CAS:1587-20-8
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 5000
- TRIMETHYL CITRATE
-
-
2026-06-30
- CAS:1587-20-8
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1000kg
- TRIMETHYL CITRATE
-
- $5.00
-
2026-05-28
- CAS:1587-20-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10000kg
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| Product Name: | Trimethyl citrate | | Synonyms: | 2,3-propanetricarboxylicacid,2-hydroxy-trimethylester;3-Hydroxy-3-methoxycarbonylpentanedioic acid, dimethyl ester;Trimethyl 2-hydroxy-1,2,3-propanetricarboxylate;CITRIC ACID TRIMETHYL ESTER;1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trimethyl ester;2-Hydroxy-1,2,3-propanetricarboxylic acid trimethyl ester;Citric acid trimethyl;2-hydroxypropane-1,2,3-tricarboxylic acid trimethyl ester | | CAS: | 1587-20-8 | | MF: | C9H14O7 | | MW: | 234.2 | | EINECS: | 216-449-2 | | Product Categories: | Miscellaneous;Functional Materials;Hydroxycarboxylic Acid Esters (Plasticizer);Plasticizer;C8 to C9;Carbonyl Compounds;Esters | | Mol File: | 1587-20-8.mol |  |
| | Trimethyl citrate Chemical Properties |
| Melting point | 75-78 °C | | Boiling point | 176 16mm | | density | 1.3363 (rough estimate) | | vapor pressure | 1.3hPa at 20℃ | | refractive index | 1.4455 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | form | Solid | | pka | 10.43±0.29(Predicted) | | color | White to Off-White | | Odor | at 100.00 %. ethereal fruity | | Odor Type | ethereal | | Water Solubility | 53.2g/L at 20℃ | | BRN | 1796169 | | InChI | 1S/C9H14O7/c1-14-6(10)4-9(13,8(12)16-3)5-7(11)15-2/h13H,4-5H2,1-3H3 | | InChIKey | HDDLVZWGOPWKFW-UHFFFAOYSA-N | | SMILES | COC(=O)CC(O)(CC(=O)OC)C(=O)OC | | LogP | 0.7 at 20℃ | | CAS DataBase Reference | 1587-20-8(CAS DataBase Reference) | | EPA Substance Registry System | 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trimethyl ester (1587-20-8) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 29181500 | | Storage Class | 11 - Combustible Solids |
| | Trimethyl citrate Usage And Synthesis |
| Description | Trimethyl citrate is an ester of citric acid. It is a kind of non-toxic plasticizer1. Trimethyl citrate is one of the constituents of Dioscorea opposita2. The IC50 value for monoamine oxidase-B of trimethyl citrate was studied. It has various applications3: it can do the main flame retardant candle flame color, its melting point and can fully meet the flammability requirements of candle products. It can be used for the synthesis of pharmaceutical and pesticide. It can act as the main raw material for the production of citric acid hydrochloride, citric acid hydrochloride as well as the synthetic hot melt adhesive. It can also be used as the methyl methacrylate polymer a blowing agent, a stabilizer acrylamide, polyamide adhesive initiators, PVC plasticizers. It can also be used as solvent for household and II cleaner, film-former4.
| | Reference |
- Huang, Li, L. I. Chun-Lian, and H. U. Qing-Guo. "Study on Catalytic Synthesis of Trimethyl Citrate by Solid Acid." Liaoning Chemical Industry (2012).
- https://www.sigmaaldrich.com/catalog/product/aldrich/27502?lang=en®ion=US
- www.zhonglanindustry.com/product/trimethyl-citrate
- https://www.lookchem.com/Trimethyl-citrate/
| | Chemical Properties | Colorless crystals. M.P. 79℃. B.P. 287℃. (decomposes). Slightly soluble in water, soluble in alcohol and oils. | | Uses | Trimethyl Citrate is a reagent used in the preparation of citrate-ciprofloxacin conjugates which has antibacterial activity. | | Preparation |
Trimethyl citrate is produced by direct esterification of Citric acid with Methanol using the old-fashioned method with 3% sulfuric acid and reflux to complete the esterification.
| | General Description | Trimethyl citrate is one of the constituents of Dioscorea opposita. The IC50 value for monoamine oxidase-B of trimethyl citrate was studied. | | Flammability and Explosibility | Not classified | | Synthesis | (i) Synthesis of trimethyl citrate
Citric acid (9.00 g, 46.8 mmol) was dissolved in anhydrous methanol and thionyl chloride (20.50 mL, 0.28 mol) was added slowly and dropwise at 0 °C and under nitrogen protection. The reaction mixture was stirred at 0 °C for 1 h, then warmed to room temperature and continued stirring overnight. Upon completion of the reaction, the volatile components were removed by distillation under reduced pressure. The resulting solid residue was recrystallized using a hexane/ethyl acetate solvent mixture to give 10.80 g of white crystalline trimethyl citrate in 98% yield.
1H NMR (acetone-d6, 200 MHz): δ 2.85 (dd, 4H, J1 = 15.4 Hz, J2 = 27.2 Hz); 3.60 (s, 6H); 3.72 (s, 3H); 4.50 (br.s, 1H).
13C NMR (acetone-d6): calculated value: M+ = 234.21. | | References | [1] Molecules, 2006, vol. 11, # 4, p. 263 - 271
[2] Patent: WO2007/14471, 2007, A1. Location in patent: Page/Page column 30
[3] Patent: US2013/89611, 2013, A1. Location in patent: Paragraph 0133-0135
[4] Molecules, 2018, vol. 23, # 9,
[5] RSC Advances, 2014, vol. 4, # 100, p. 57297 - 57307 |
| | Trimethyl citrate Preparation Products And Raw materials |
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