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| | m-PEG5-succinimidyl carbonate Basic information |
| Product Name: | m-PEG5-succinimidyl carbonate | | Synonyms: | m-PEG5-succinimidyl carbonate;2,5,8,11,14,17-Hexaoxaoctadecanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;14-methoxy-3,6,9,12-tetraoxa tetradecanyl N-succinimidyl carbonate | | CAS: | 1058691-00-1 | | MF: | C16H27NO10 | | MW: | 393.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1058691-00-1.mol |  |
| | m-PEG5-succinimidyl carbonate Chemical Properties |
| Boiling point | 469.3±55.0 °C(Predicted) | | density | 1.25±0.1 g/cm3(Predicted) | | form | Liquid | | color | Colorless to light yellow |
| | m-PEG5-succinimidyl carbonate Usage And Synthesis |
| Description | m-PEG5-succinimidyl carbonate is a PEG linker with an attached succinumidyl carbonate group. The succinimidyl carbonate group is a good leaving group and commonly reacts with amine nucleophiles. | | Uses | m-PEG5-succinimidyl carbonate is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG5-succinimidyl carbonate is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. | | IC 50 | PEGs; Alkyl/ether; Non-cleavable Linker | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005 |
| | m-PEG5-succinimidyl carbonate Preparation Products And Raw materials |
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