QLKKMIWGFNMQJQ-JZFYYOKZSA-N

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QLKKMIWGFNMQJQ-JZFYYOKZSA-N Basic information
Product Name:QLKKMIWGFNMQJQ-JZFYYOKZSA-N
Synonyms:QLKKMIWGFNMQJQ-JZFYYOKZSA-N;17-trifluoromethylphenyl trinor Prostaglandin F2.alpha. ethyl amide;9α,11α,15S-trihydroxy-17-trifluoromethylphenyl-18,19,20-trinor-prosta-5Z,13E-dien-1-oic acid, ethyl amide;5-Heptenamide, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]-1-penten-1-yl]cyclopentyl]-N-ethyl-, (5Z)-;17-trifluoromethylphenyl trinor Prostaglandin F2α ethyl amide
CAS:1621369-73-0
MF:C26H36F3NO4
MW:483.56
EINECS:
Product Categories:
Mol File:1621369-73-0.mol
QLKKMIWGFNMQJQ-JZFYYOKZSA-N Structure
QLKKMIWGFNMQJQ-JZFYYOKZSA-N Chemical Properties
Boiling point 626.1±55.0 °C(Predicted)
density 1.220±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 25 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .15 mg/ml
pka14.25±0.20(Predicted)
Safety Information
MSDS Information
QLKKMIWGFNMQJQ-JZFYYOKZSA-N Usage And Synthesis
DescriptionProstaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity. 17-trifluoromethylphenyl trinor Prostaglandin F2α (17-trifluoromethylphenyl trinor PGF2α) is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF2α ethyl amide is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α. Ethyl amides of PGs can serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.
Uses17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide (compound 17-CF3PTPG2α EA) is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α[1].
References[1] Wittenberg JB, et al. Determination of prostaglandin analogs in cosmetic products by high performance liquid chromatography with tandem mass spectrometry. J Chromatogr A. 2014;1359:140-146. DOI:10.1016/j.chroma.2014.07.032
QLKKMIWGFNMQJQ-JZFYYOKZSA-N Preparation Products And Raw materials
Tag:QLKKMIWGFNMQJQ-JZFYYOKZSA-N(1621369-73-0) Related Product Information
BiMatoprost IMpurity III 17-trifluoromethylphenyl trinor Prostaglandin F2α isopropyl ester 17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-5-phenoxypent-1-enyl]cyclopentyl]-N-ethylhept-5-enamide 17-phenyl trinor Prostaglandin F2α ethyl amide-d4 15-Keto prostaglandin E2