17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester

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17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Basic information
Product Name:17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester
Synonyms:17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester;17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Exclusive;SPNWWFJGYHYDNY-HCAGXNQISA-N;17-trifluoromethylphenyl trinor Prostaglandin F2.alpha. methyl ester;5-Heptenoic acid, 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-[3-(trifluoromethyl)phenyl]-1-penten-1-yl]cyclopentyl]-, methyl ester, (5Z)-
CAS:195503-20-9
MF:C25H33F3O5
MW:470.52
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Mol File:195503-20-9.mol
17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Structure
17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Chemical Properties
Boiling point 556.7±50.0 °C(Predicted)
density 1.246±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 25 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .15 mg/ml
pka14.25±0.20(Predicted)
Safety Information
MSDS Information
17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Usage And Synthesis
DescriptionProstaglandin F2α (PGF2α), acting through the FP receptor, causes smooth muscle contraction and exhibits potent luteolytic activity.1,2,3 17-trifluoromethylphenyl trinor PGF2α is an analog of PGF2α that shares the meta-trifluoromethyl group of travoprost with the 17-phenyl trinor modification of latanoprost. It is anticipated to be a potent and selective agonist of the FP receptor, with potential applications in glaucoma and luteolysis. 17-trifluoromethylphenyl trinor PGF2α methyl ester is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α. Methyl esters of PGs serve as prodrugs, as they are efficiently hydrolyzed in certain tissues to generate the bioactive free acid.
Uses17-Trifluoromethylphenyl trinor prostaglandin F2α methyl ester is an analog of PGF2α[1].
References1. Samuelsson, B., Goldyne, M., Granstrm, E., et al. Prostaglandins and thromboxanes Annu. Rev. Biochem. 47,997-1029(1978).
2. Speroff, L., and Ramwell, P.W. Prostaglandins in reproductive physiology Am. J. Obstet. Gynecol. 107(7),1111-1130(1970).
3. Crankshaw, D.J., and Gaspar, V. Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewes J. Reprod. Fertil. 103(1),55-61(1995).
17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester Preparation Products And Raw materials
Tag:17-trifluoromethylphenyl trinor Prostaglandin F2α methyl ester(195503-20-9) Related Product Information
(Z)-7-[(1R,2R,3R,5S)-3,5-DIHYDROXY-2-((E)-(S)-3-HYDROXY-5-PHENYL-PENT-1-ENYL)-CYCLOPENTYL]-HEPT-5-ENOIC ACID METHYL ESTER 17-trifluoromethylphenyl trinor Prostaglandin F2α isopropyl ester 17-TRIFLUOROMETHYLPHENYL TRINOR PROSTAGLANDIN F2ALPHA 17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α QLKKMIWGFNMQJQ-JZFYYOKZSA-N 15-KETO PROSTAGLANDIN E2