CLASTO-LACTACYSTIN BETA-LACTONE,20S PROTEASOME抑制剂
| 中文名称 | CLASTO-LACTACYSTIN BETA-LACTONE,20S PROTEASOME抑制剂 |
|---|---|
| 中文同义词 | CLASTO-LACTACYSTIN BETA-LACTONE,20S PROTEASOME抑制剂;clasto-Lactacystin β-lactone试剂;clasto-Lactacystin β-lactone试剂 |
| 英文名称 | Clasto-Lactacystin ?-lactone |
| 英文同义词 | OMURALIDE;LACTACYSTIN, CLASTO-, BETA-LACTONE;BETA-CLASTOLACTACYSTIN;CLASTO-LACTACYSTIN BETA-LACTONE;1R-[1S-1HYDROXY-2-METHYLPROPYL]-4R-METHYL-6-OXA-2-AZABICYCLO[3.2.0]HEPTANE-3,7-DIONE;Clasto-lactacystin (OMuralide);(1R,4R,5S)-1-[(1S)-1-Hydroxy-2-Methylpropyl]-4-Methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione;6-Oxa-2-azabicyclo[3.2.0]heptane-3,7-dione, 1-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-, (1R,4R,5S)- |
| CAS号 | 154226-60-5 |
| 分子式 | C10H15NO4 |
| 分子量 | 213.23 |
| EINECS号 | |
| 相关类别 | Calpain and Proteasome InhibitorsProteasome, Calpain and Lysosomal Proteases;InhibitorsProtease Inhibitors;Proteasome inhibitor;Proteasome inhibitorEnzyme Inhibitors by Enzyme;Intracellular Protein Degradation;Nitric Oxide and Cell Stress;P to;Protease Inhibitor Specificity Index;Proteasomes;Inhibitors;ProteasomeInhibitors |
| Mol文件 | 154226-60-5.mol |
| 结构式 |  |
CLASTO-LACTACYSTIN BETA-LACTONE,20S PROTEASOME抑制剂 性质
| 熔点 | 186-187°C |
|---|---|
| 沸点 | 440.815±40.00 °C(Press: 760.00 Torr)(predicted) |
| 密度 | 1.280±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| 储存条件 | -20°C |
| 溶解度 | DMF、乙醇、热乙酸乙酯、甲醇、吡啶 |
| 形态 | 白色固体 |
| 酸度系数(pKa) | 13.332±0.20(predicted) |
| 颜色 | 白色 |
| InChI | 1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1 |
| InChIKey | FWPWHHUJACGNMZ-NBBQQVJHSA-N |
| SMILES | [H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C |
CLASTO-LACTACYSTIN BETA-LACTONE,20S PROTEASOME抑制剂 是一种天然的 lactacystin (Streptomyces 代谢物) 的活性代谢物，为 20S proteasome 的不可逆抑制剂。
安全信息
| 危险品标志 | T |
|---|---|
| 危险类别码 | 20/21/22-37/38-41-36/37/38-25 |
| 安全说明 | 16-26-36/37/39-45 |
| 危险品运输编号 | UN 2811 6.1 / PGIII |
| WGK Germany | 2 |
| 存储类别 | 11 - 可燃固体 |
| 危险性类别 | 眼部刺激 类别2 |
| 提供商 | 语言 |
|---|---|
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英文
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