2-(3-羧基丙基)-3-氨基-6-(4-甲氧苯基)吡啶溴化
| 中文名称 | 2-(3-羧基丙基)-3-氨基-6-(4-甲氧苯基)吡啶溴化 |
|---|---|
| 中文同义词 | 2-(3-羧基丙基)-3-氨基-6-(4-甲氧苯基)吡啶溴化物;4-(6-亚氨基-3-(4-甲氧苯基)哒嗪-1(6H)-基)丁酸氢溴酸盐;SR-95531,GABA A拮抗剂;SR95531 (GABAZINE) (MM/ML),GABAA拮抗剂;SR95531 (GABAZINE),GABAA拮抗剂;克他命,10 MM DMSO 溶液;Gabazine 拮抗剂;SR-95531【S106】 |
| 英文名称 | SR-95531 |
| 英文同义词 | Gabazine, 2-(3-Carboxypropyl)-3-amino-6-(4 methoxyphenyl)pyridazinium bromide;1(6H)-Pyridazinebutanoic acid, 6-imino-3-(4-methoxyphenyl)-, monohydrobromide;6-Amino-5-methyl-3-(4-methoxyphenyl)-1-pyridaziniumbutyric acid br;6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid monohydrobromide;Gabazine Hydrobromide;4-(6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl)butanoic acid hydrobromide;GABAZINE BROMIDE;2-(3-CARBOXYPROPYL)-3-AMINO-6-(4-METHOXYPHENYL)PYRIDAZINIUM |
| CAS号 | 104104-50-9 |
| 分子式 | C15H18BrN3O3 |
| 分子量 | 368.23 |
| EINECS号 | |
| 相关类别 | GABA/Glycine receptor |
| Mol文件 | 104104-50-9.mol |
| 结构式 |  |
2-(3-羧基丙基)-3-氨基-6-(4-甲氧苯基)吡啶溴化 性质
| 熔点 | 200 °C(Solv: ethanol (64-17-5)) |
|---|---|
| 储存条件 | Store at RT |
| 溶解度 | 在DMSO中的溶解度为30 毫克/毫升 |
| 形态 | 固体 |
| 颜色 | 白色 |
| 水溶解性 | water: 25mM |
| InChI | 1S/C15H17N3O3.BrH/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20;/h4-9,16H,2-3,10H2,1H3,(H,19,20);1H |
| InChIKey | GFZHNFOGCMEYTA-UHFFFAOYSA-N |
| SMILES | [Br-].COc1ccc(cc1)-c2ccc(N)[n+](CCCC(O)=O)n2 |
0.2 μM (GABA receptor).
Both bicuculline and Gabazine (SR 95531) have been characterized as competitive inhibitors of GABA binding to the GABA A receptor. Gabazine is more potent than bicuculline at blocking currents elicited by GABA, with an IC 50 for currents elicited by 3 μM GABA of ~0.2 μM and a Hill coefficient of 1.0. Gabazine reduces the currents elicited by 10 μM alphaxalone by ~30%, for responses of receptors containing wildtype β2 subunits. The concentration of Gabazine requires producing half the maximal block is ~0.2 μM. Gabazine also could only produce a partial block of currents gated by 300 μM pentobarbital. The maximal reduction, again, is ~30%, and the concentration of Gabazine required to produce half the maximal block is ~0.15 μM.
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
|
英文
|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-103533R | 2-(3-羧基丙基)-3-氨基-6-(4-甲氧苯基)吡啶溴化 Gabazine (Standard) | 104104-50-9 | 5 mg | 1400元 |
| 2026/06/05 | HY-103533 | 2-(3-羧基丙基)-3-氨基-6-(4-甲氧苯基)吡啶溴化 Gabazine | 104104-50-9 | 1 mg | 272元 |