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| | BIS(2,4-DINITROPHENYL) CARBONATE Basic information |
| | BIS(2,4-DINITROPHENYL) CARBONATE Chemical Properties |
| Melting point | 148 °C(Solv: benzene (71-43-2)) | | Boiling point | 583.5±50.0 °C(Predicted) | | density | 1.741±0.06 g/cm3(Predicted) | | solubility | sol EtOAc, pyridine, DMF, CHCl3; moderately sol benzene; insol hexane; dec hot H2O, EtOH | | color | yellow solid |
| | BIS(2,4-DINITROPHENYL) CARBONATE Usage And Synthesis |
| Description | Bis(2,4-dinitrophenyl)carbonate is used in the preparation of azapeptides. | | Uses | Peptide and azapeptide coupling reagent that functions by activating amines, forming derivatives suitable for condensation with N-protected amino acids; converts carboxylic acids to activated esters.
| | Synthesis | Diphenyl carbonate (20 g) is added to a stirred mixture of conc HNO3 (100 mL) and conc H2SO4 (120 mL) at 50-55 °C over 1 h. The resulting suspension is stirred at 50 °C for 3 h, left at rt for 90 h and poured onto ice. The precipitate is washed with iced water and dried in vacuo over P2O5. This affords bis(2,4-dinitrophenyl) carbonate (31.2 g, 85%) which recrystallizes from hexane/benzene giving crystals, mp 144-146 °C. | | Precautions | Store in a cool dry place to preclude contact with moisture; the hazardous and toxicological properties have not been investigated; may explode if heated rapidly
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| | BIS(2,4-DINITROPHENYL) CARBONATE Preparation Products And Raw materials |
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