|
|
| | 5-(3-Chloro-phenyl)-[1,3,4]thiadiazol-2-ylamine Basic information |
| Product Name: | 5-(3-Chloro-phenyl)-[1,3,4]thiadiazol-2-ylamine | | Synonyms: | 1,3,4-Thiadiazol-2-amine, 5-(3-chlorophenyl)-;2-Amino-5-(3-chlorophenyl)-1,3,4-thiadiazole;5-(3-CHLOROPHENYL)-1,3,4-THIADIAZOL-2-AMINE;5-(3-Chloro-phenyl)-[1,3,4]thiadiazol-2-ylamine | | CAS: | 70057-67-9 | | MF: | C8H6ClN3S | | MW: | 211.67 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![5-(3-Chloro-phenyl)-[1,3,4]thiadiazol-2-ylamine Structure](StructureFile/ChemBookStructure5/GIF/CB9424119.gif) |
| | 5-(3-Chloro-phenyl)-[1,3,4]thiadiazol-2-ylamine Chemical Properties |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| | 5-(3-Chloro-phenyl)-[1,3,4]thiadiazol-2-ylamine Usage And Synthesis |
| Synthesis | 5.1.1 Synthesis of 5-(3-chlorophenyl)-1,3,4-thiadiazol-2-amine (67): 3-chlorobenzoic acid (5.18 g, 25 mmol) and N-amino thiourea (2.28 g, 25 mmol) were dissolved in POCl3 (7 ml), and the reaction was stirred vigorously for 0.5 hr at 75 °C. After completion of the reaction, H2O (30 ml) was added and the reaction mixture was heated to reflux for 4 hours. Subsequently, the reaction solution was adjusted with 50% NaOH solution to pH 8. The reaction mixture was filtered and the filter cake was recrystallized with ethanol to give the target product 67 as yellow crystals. Yield: 75%; Melting point: 212-214 °C (EtOH). eSI-MS m/z: 212.1 [M + H]+; 1H NMR (CDCl3) δ 7.49-7.50 (m, 2H), 7.54 (s, 2H), 7.70-7.71 (m, 1H), 7.80 (s, 1H). | | References | [1] Journal of Chemical Research, 2011, vol. 35, # 12, p. 703 - 706
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5766 - 5775
[3] Journal of Chemical Research, 2012, vol. 36, # 4, p. 218 - 221
[4] Pharmazie, 2018, vol. 73, # 3, p. 123 - 127
[5] Bioorganic Chemistry, 2018, vol. 81, p. 88 - 92 |
| | 5-(3-Chloro-phenyl)-[1,3,4]thiadiazol-2-ylamine Preparation Products And Raw materials |
|