- N-Aminothiourea
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2026-09-11
- CAS:79-19-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200mt
- thiosemicarbazide
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- $999.00
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2026-09-11
- CAS:79-19-6
- Min. Order: 1ton
- Purity: 99%
- Supply Ability: 5000
Related articles - Applications of Thiosemicarbazide
- Thiosemicarbazide(1-Amino-2-thiourea,TSG) is a white crystalline powder and is odorless. It will dissolve in water. This mater....
- Nov 1，2019
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| | Thiosemicarbazide Basic information |
| | Thiosemicarbazide Chemical Properties |
| Melting point | 180-183 °C (dec.)(lit.) | | Boiling point | 208.6±23.0 °C(Predicted) | | density | 1.221 (estimate) | | bulk density | 500-600kg/m3 | | vapor pressure | 1.15Pa at 25℃ | | refractive index | 1.5800 (estimate) | | storage temp. | Store at +15°C to +25°C. | | solubility | DMSO : 125 mg/mL (1371.52 mM; Need ultrasonic) | | pka | pK1:1.5(+1) (25°C,μ=0.1) | | form | Powder | | color | White to light yellow | | PH | 5-7 (50g/l, H2O, 20℃) | | biological source | rabbit | | Water Solubility | soluble | | Merck | 14,9361 | | BRN | 506320 | | Henry's Law Constant | 1.5×104 mol/(m3Pa) at 25℃, HSDB (2015) | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChI | 1S/CH5N3S/c2-1(5)4-3/h3H2,(H3,2,4,5) | | InChIKey | BRWIZMBXBAOCCF-UHFFFAOYSA-N | | SMILES | NNC(N)=S | | LogP | -1.67 | | CAS DataBase Reference | 79-19-6(CAS DataBase Reference) | | NIST Chemistry Reference | Hydrazinecarbothioamide(79-19-6) | | EPA Substance Registry System | Thiosemicarbazide (79-19-6) |
| Hazard Codes | T+ | | Risk Statements | 28-52/53-26/27/28 | | Safety Statements | 22-26-36/37-45-61-28A-36/37/39 | | RIDADR | UN 2811 6.1/PG 2 | | WGK Germany | 3 | | RTECS | VT4200000 | | F | 8-9-23 | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | II | | HS Code | 29309070 | | HS Code | 29335995 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Oral
Aquatic Chronic 3 | | Hazardous Substances Data | 79-19-6(Hazardous Substances Data) | | Toxicity | LD50 orally in adult Norway rats: 13 mg/kg, Dieke, Proc. Soc. Exp. Biol. Med. 70, 688 (1949) |
| | Thiosemicarbazide Usage And Synthesis |
| Chemical Properties | Thiosemicarbazide is an odorless, white crystalline powder. It is soluble in water and ethanol; its solubility in cold water is 1%–2%, and in warm water is approximately 10%. Needle-like crystals can be obtained from aqueous solutions. It readily reacts with aldehydes and ketones to form specific crystalline products; it also readily reacts with carboxylic acids. | | Uses | Used in TLC to stain alpha-keto acidsThiosemicarbazide is used as a reagent for ketones as well as chemical intermediate. It is involved in the detection of metals. It is also used in photography. Further, it is effective for controlling bacterial leaf blight in rice. In addition to this, it is used to prepare 1,3,4-thiadiazoles. | | Uses | As a reagent for detection of metals. | | Preparation | Thiosemicarbazide is produced from hydrazine hydrate and ammonium thiocyanate as raw materials, with acetaldehyde used as a catalyst. The chemical equations are as follows:
2H₂NNH₂·H₂O + H₂SO₄ → (H₂NNH₂)₂·H₂SO₄ + 2H₂O
(H₂NNH₂)₂·H₂SO₄ + 2NH₄SCN → 2H₂NNH₂·HSCN + (NH₄)₂SO₄ | | Definition | ChEBI: Hydrazinecarbothioamide is a member of the class of thioureas that is thiourea in which a hydrogen of one of the amino groups is replaced by an amino group. It is a member of hydrazines, a thiocarboxamide and a member of thioureas. | | General Description | N-Aminothiourea is a white crystalline powder and is odorless. N-Aminothiourea is used as a reagent for ketones and certain metals, for photography and as a rodenticide. N-Aminothiourea is also effective for control of bacterial leaf blight of rice. Not a registered pesticide in the U.S. N-Aminothiourea is a chemical intermediate for herbicides and a reagent for detection of metals. | | Reactivity Profile | Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)]. | | Health Hazard | N-Aminothiourea is highly toxic by ingestion. May induce goiter and cause delayed toxic effects in blood and skin. May be mutagenic in human cells. | | Fire Hazard | When heated to decomposition, very toxic fumes of sulfur oxides and nitrogen oxides are emitted. | | Flammability and Explosibility | Non flammable | | Safety Profile | Poison by ingestion,
intraperitoneal, and intravenous routes.
Questionable carcinogen with experimental
tumorigenic data. Human mutation data
reported. When heated to decomposition it
emits very toxic fumes of NOx and SOx. | | Potential Exposure | Thiosemicarbazide is a dithiocarbamide compound is used as an intermedialte for pharmaceuticals and herbicides; as a reagent for ketones and certain metals; in certain photography and dye operations; as a rodenticide. It is also effective for control of bacterial leaf blight of rice. | | Shipping | UN2771 Thiosemicarbazide, pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. | | Purification Methods | Crystallise thiosemicarbazide from H2O (solubility is 20.3% w/w at 80o). The hydrochloride has m 190-191o(dec, 184o also reported). It forms salts with heavy metals. [Beilstein 3 H 195, 3 I 79, 3 II 134, 3 III 315, 3 IV 374.] | | Incompatibilities | Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.) and strong reducing agents; contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. May react with nitrates. | | References | [1] Kurihara, H., et al. “Synthesis of Cyanohydrazine Derivatives from Thiosemicarbazide. Alkylating Reaction of Thiosemicarbazide Using Phase-Transfer Catalyst.” Nippon Kagaku Kaishi, 83 1, 1997, pp. 412–18, https://doi.org/10.1246/NIKKASHI.1997.412.
[2] Varvaresou, Athanasia, et al. “ChemInform Abstract: Synthesis and Biological Evaluation of Indole Containing Derivatives of Thiosemicarbazide and Their Cyclic 1,2,4-Triazole and 1,3,4-Thiadiazole Analogues.” ChemInform, 31 15, 2010, https://doi.org/10.1002/chin.200015117. |
| | Thiosemicarbazide Preparation Products And Raw materials |
| Raw materials | Thiourea-->Ammonium thiocyanate-->Hydrazine sulfate | | Preparation Products | CEFTRIAXONE-->2-Chloropyrimidine-4-carboxylic acid-->Robenidine hydrochloride-->BISMERTHIAZOL-->5-amino-1,3,4-thiadiazole-2-carboxylic acid-->CAFENSTROLE-->5-Amino-1,3,4-thiadiazole-2-carboxylic acid ethyl ester-->Azidithion-->1,2,3,4-Thiatriazol-5-amine-->3-tert-butyl-1H-1,2,4-triazole-5-thiol-->Rubber auxiliary-->2-tirfluoromethylpyridine-->1H-1,2,4-Triazole-3-thiol-->2-Amino-5-methyl-1,3,4-thiadiazole-->4-thiadiazole,2-amino-5-pentyl-3-->ETHYL 1-(4-PHENYL-1,3-THIAZOL-2-YL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE |
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