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| | 4-Amino-2-nitro-benzoic acid ethyl ester Basic information |
| | 4-Amino-2-nitro-benzoic acid ethyl ester Chemical Properties |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| | 4-Amino-2-nitro-benzoic acid ethyl ester Usage And Synthesis |
| Synthesis | General steps:
1. dissolve 4-acetamido-2-nitrobenzoic acid (1.80 g, 8.0 mmol) in a mixture of 12 N hydrochloric acid (14 mL) and anhydrous ethanol (10 mL).
2. The reaction mixture was heated to 90-100°C and kept for 5 hours.
3. Upon completion of the reaction, the ethanol is removed by vacuum concentration.
4. The pH of the reaction mixture was adjusted to 4 with 1 N sodium hydroxide solution.
5. The precipitate was collected by filtration to give ethyl 4-amino-2-nitrobenzoate (140 mg, 8% yield).
Product characterization data:
1H-NMR (CDCl3): δ 7.61 (d, J = 8.5 Hz, 1H), 6.82 (d, J = 2.1 Hz, 1H), 6.74 (dd, J = 8.5, 2.1 Hz, 1H), 6.52 (bs, 2H), 4.17 (q, J = 7.1 Hz, 2H), 1.21 (t, J = 7.1 Hz, 3H); MS ( DCI) m/e: 211 (MH+). | | References | [1] Patent: US5618839, 1997, A
[2] Patent: US5648385, 1997, A |
| | 4-Amino-2-nitro-benzoic acid ethyl ester Preparation Products And Raw materials |
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