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| | 2,6-DIBROMO-4-TERT-BUTYL-PHENOL Basic information |
| Product Name: | 2,6-DIBROMO-4-TERT-BUTYL-PHENOL | | Synonyms: | 2,6-DIBROMO-4-TERT-BUTYL-PHENOL;NSC 74538;Phenol, 2,6-dibroMo-4-(1,1-diMethylethyl)-;4-tert-Butyl-2,6-dibromophenol;6-Dibromo-4-(tert-butyl)phenol | | CAS: | 98-22-6 | | MF: | C10H12Br2O | | MW: | 308.01 | | EINECS: | | | Product Categories: | | | Mol File: | 98-22-6.mol |  |
| | 2,6-DIBROMO-4-TERT-BUTYL-PHENOL Chemical Properties |
| Melting point | 70-71℃ | | Boiling point | 256℃ | | density | 1.647 | | Fp | 108℃ | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | color | Off-white |
| | 2,6-DIBROMO-4-TERT-BUTYL-PHENOL Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2,6-dibromo-4-tert-butylphenol and 2-bromo-4-tert-butylphenol from 4-tert-butylphenol: A solution of 4-tert-butylphenol (ca. 10 mmol) and p-toluenesulfonic acid (pTsOH, 10 mol%) in methanol (MeOH, 1.0 mL/mmol of raw material) was stirred for 10 min. Subsequently, a methanol solution (0.1 M) of N-bromosuccinimide (NBS, 100 mol%, recrystallized from H2O) was added dropwise from a foil reaction flask over 20 min. The reaction mixture was continued to be stirred for 5 min and then concentrated in vacuum. The resulting residue was purified by column chromatography with the eluent being dichloromethane (CH2Cl2) or a dichloromethane solution containing 1% methanol. Product characterization: 2-bromo-4-methylphenol (10) [23]: 10.1 mmol; 1.73 g (92% yield). | | References | [1] Molecules, 2016, vol. 21, # 1,
[2] Tetrahedron, 2009, vol. 65, # 22, p. 4429 - 4439 |
| | 2,6-DIBROMO-4-TERT-BUTYL-PHENOL Preparation Products And Raw materials |
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