醉茄素 A
| 中文名称 | 醉茄素 A |
|---|---|
| 中文同义词 | 醉茄素 A,来源于睡茄叶;霜抑素A;WITHAFERIN A STANDARD;WITHAFERIN A BIOCHEMICA;(4S,4AR,5AR,6AS,6BS,9R,9AS,11AS,11BR)-4-羟基-9-((S)-1-((R)-5-(羟甲基)-4-甲基-6-氧代-3,6-二氢-2H-吡喃-2-基)乙基)-9A,11B二甲基-5A,6,6A,6B,7,8,9,9A,10,11,11A,11B十二氢环戊[1,2]菲[8A,9-B]氧-1(4H)-酮;乙腈中醉茄素A;醉茄素;醉茄素A/HPLC |
| 英文名称 | WITHAFERIN A |
| 英文同义词 | WITHAFERIN A;5,6-beta-epoxy-4-beta,22,27-trihydroxy-1-5-beta-ergosta-24-dien-26-oicacid;delta-lactone,(20s,22r)-oxo;nsc-101088;(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone;NSC 273757;Withaferine;(20S,22R)-5,6β-Epoxy-4β,22,27-trihydroxy-1-oxo-5β-ergosta- 2,24-dien-26-oic Acid δ-Lactone |
| CAS号 | 5119-48-2 |
| 分子式 | C28H38O6 |
| 分子量 | 470.6 |
| EINECS号 | 999-999-2 |
| 相关类别 | 分析试剂标准品;中药对照品;生化试剂;合成;新品;对照品;标准品，对照品;化工原料;标准品-对照品;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;antibiotic |
| Mol文件 | 5119-48-2.mol |
| 结构式 |  |
醉茄素 A 性质
| 熔点 | 252-253℃ |
|---|---|
| 比旋光度 | D28 +125° (c = 1.30 in CHCl3) |
| 沸点 | 680.7±55.0 °C(Predicted) |
| 密度 | 1.28 |
| 闪点 | 226℃ |
| 储存条件 | Desiccate at -20°C |
| 溶解度 | 可溶于 DMSO（高达 20 mg/ml） |
| 酸度系数(pKa) | 13.49±0.70(Predicted) |
| 形态 | 白色固体 |
| 颜色 | 白色 |
| 生物来源 | plant (Withania somnifera) |
| 稳定性 | 可在-20°C下的DMSO溶液保存长达1个月。 |
| 主要应用 | food and beverages |
| InChIKey | DBRXOUCRJQVYJQ-CKNDUULBSA-N |
| SMILES | C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)[C@H]4CC[C@]23C |
| Target | Value |
|
NF-κB
() | |
|
vimentin
() |
Withaferin A has antiinflammatory activity, and potently inhibits NF-kB activation by preventing the TNF-induced activation of Ik-B kinase beta via a thioalkylation-sensitive redox mechanism. Withaferin A also has anticancer activity. Withaferin A targets the IF protein vimentin, causes aggregation of vimentin filaments in bovine aortic endothelial cells (BAECs) at 3 μM, and induces vimentin fragmentation in endothelial cells at 10 μM. Withaferin A (0.5, 1.5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs).
Withaferin A (2 mg/kg, i.p.) shows potent angiogenesis inhibitory activity via vimentin in mice. Withaferin A (2 mg/kg) combined with cisplatin (CIS) regulates the expression of ALDH1 marker, and downregulates the expression of securin in tumors collected from mice.
安全信息
| 危险品标志 | T |
|---|---|
| WGK Germany | 3 |
| RTECS号 | KE7288500 |
| 海关编码 | 29322090 |
| 存储类别 | 11 - 可燃固体 |