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| | Amylin (8-37) (human) (trifluoroacetate salt) Basic information |
| | Amylin (8-37) (human) (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | Amylin (8-37) (human) (trifluoroacetate salt) Usage And Synthesis |
| Description | Amylin (8-37) is a peptide fragment of amylin (Item Nos. 24274 | 24275).1 It inhibits osteoblast proliferation, but not bone resorption, induced by full-length human amylin and does not act as an agonist at amylin receptors. Amylin (8-37) induces formation of polymorphic fibrils containing coiled and laterally-associated sheet structures.2 It is cytotoxic to RINm5F islet β-cells in vitro when used at a concentration of 25 µM, an effect that is inversely correlated with mature fibril content.3WARNING This product is not for human or veterinary use. | | References | [1] J CORNISH. Dissociation of the effects of amylin on osteoblast proliferation and bone resorption.[J]. American Journal of Physiology, 1998, 274 5: E827-33. DOI: 10.1152/ajpendo.1998.274.5.e827
[2] C. GOLDSBURY . Amyloid Fibril Formation from Full-Length and Fragments of Amylin[J]. Journal of structural biology, 2000, 130 2: Pages 352-362. DOI: 10.1006/jsbi.2000.4268
[3] BARBARA KONARKOWSKA. The aggregation potential of human amylin determines its cytotoxicity towards islet β-cells[J]. The FEBS journal, 2006, 273 15: 3614-3624. DOI: 10.1111/j.1742-4658.2006.05367.x |
| | Amylin (8-37) (human) (trifluoroacetate salt) Preparation Products And Raw materials |
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