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| | Amylin (human) (amidated) (trifluoroacetate salt) Basic information |
| | Amylin (human) (amidated) (trifluoroacetate salt) Chemical Properties |
| solubility | Water: 1 mg/ml |
| | Amylin (human) (amidated) (trifluoroacetate salt) Usage And Synthesis |
| Description | Amylin is a peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety.1 Native amylin is a cleavage product of proamylin that is processed and amidated at the C-terminus, a modification that is required for its biological activities.2 Amidated amylin increases the rate of glycogen synthesis induced by insulin in isolated rat soleus muscle when used at a concentration of 1 nM, while linear non-amidated amylin has no effect. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes and, in vitro, amidated amylin is more amyloidogenic than the free acid form.3,4 Amylin (human) (amidated) is a 37-residue amidated form of amylin that contains a disulfide bridge between cysteines two and seven.WARNING This product is not for human or veterinary use. | | References | [1] LUTZ T A. Control of food intake and energy expenditure by amylin-therapeutic implications.[J]. International Journal of Obesity, 2009, 33 Suppl 1: S24-7. DOI: 10.1038/ijo.2009.13
[2] A N ROBERTS. Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1989, 86 24: 9662-9666. DOI: 10.1073/pnas.86.24.9662
[3] G J COOPER. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1987, 84 23: 8628-8632. DOI: 10.1073/pnas.84.23.8628
[4] ISAAC T. YONEMOTO. Amylin Proprotein Processing Generates Progressively More Amyloidogenic Peptides that Initially Sample the Helical State†[J]. Biochemistry Biochemistry, 2008, 47 37: 9900-9910. DOI: 10.1021/bi800828u |
| | Amylin (human) (amidated) (trifluoroacetate salt) Preparation Products And Raw materials |
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