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| | Salvinorin A Carbamate Basic information |
| Product Name: | Salvinorin A Carbamate | | Synonyms: | Salvinorin A Carbamate;2H-Naphtho[2,1-c]pyran-7-carboxylic acid, 9-[(aminocarbonyl)oxy]-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-, methyl ester, (2S,4aR,6aR,7R,9S,10aS,10bR)-;(2S,4aR,6aR,7R,9S,10aS,10bR)-9-[(aminocarbonyl)oxy]-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylicacid,methylester;Methyl (2S,4aR,6aR,7R,9S,10aS,10Br)-9-carbamoyloxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10-dioxo-2,4a,5,6,7,8,9,10a-octahydro-1H-benzo[f ]isochromene-7-carboxylate | | CAS: | 858345-57-0 | | MF: | C22H27NO8 | | MW: | 433.45 | | EINECS: | | | Product Categories: | | | Mol File: | 858345-57-0.mol |  |
| | Salvinorin A Carbamate Chemical Properties |
| Boiling point | 627.8±55.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Acetonitrile: 1 mg/ml; DMF: 1 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 12.93±0.50(Predicted) |
| | Salvinorin A Carbamate Usage And Synthesis |
| Description | Salvinorin A carbamate is a potent κ-opioid receptor (KOR) full agonist that is almost as potent as salvinorin A with EC50 values of 6.2 and 4.5 nM, respectively, for activation of the human KOR to enhance binding of [35S]GTPγS. The addition of a carbamate group to salvinorin A increases biological stability by decreasing deacetylation. | | Uses | Salvinorin A carbamate is an agonist for κ-opioid receptor with an EC50 of 6.2 nM and a Ki of 3.2 nM[1]. | | IC 50 | κ Opioid Receptor/KOR: 6.2 nM (EC50) | | References | [1] Béguin C, et al., Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2). Bioorg Med Chem Lett. 2005 Jun 2;15(11):2761-5. DOI:10.1016/j.bmcl.2005.03.113 |
| | Salvinorin A Carbamate Preparation Products And Raw materials |
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