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| | YM-53403 Basic information |
| Product Name: | YM-53403 | | Synonyms: | YM-53403;YM 53403,YM53403;4H-Thieno[3,2-d][1]benzazepine-2-carboxamide, 6-[4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]benzoyl]-N-cyclopropyl-5,6-dihydro- | | CAS: | 851331-05-0 | | MF: | C36H29N3O3S | | MW: | 583.7 | | EINECS: | | | Product Categories: | | | Mol File: | 851331-05-0.mol |  |
| | YM-53403 Chemical Properties |
| Boiling point | 787.9±60.0 °C(Predicted) | | density | 1.39±0.1 g/cm3(Predicted) | | pka | 12.31±0.20(Predicted) |
| | YM-53403 Usage And Synthesis |
| Description | YM-53403 is a respiratory syncytial virus (RSV) inhibitor. YM-53403 potently inhibited the replication of RSV strains belonging to both A and B subgroups, but not influenza A virus, measles virus, or herpes simplex virus type 1. A plaque reduction assay was used to determine the 50% effective concentration (EC(50)) value for YM-53403. The value, 0.20 microM, was about 100-fold more potent than ribavirin. YM-53403 is an attractive compound for the treatment of RSV infection because of its highly potent anti-RSV activity and the new mode of action, which differs from that of currently reported antiviral agents. | | Uses | YM 53403 is an anti-respiratory syncytial virus (RSV) agent, with an EC50 of 0.20 μM. YM 53403 potently inhibits the replication of RSV strains belonging to both A and B subgroups[1]. | | References | [1] Sudo K, et al. YM-53403, a unique anti-respiratory syncytial virus agent with a novel mechanism of action. Antiviral Res. 2005 Feb;65(2):125-31. DOI:10.1016/j.antiviral.2004.12.002 |
| | YM-53403 Preparation Products And Raw materials |
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