AT-130
(AT130) manufacturers
- AT-130
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- $35.00
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2026-07-14
- CAS:211364-06-6
- Purity: 98.62%
- Supply Ability: 10g
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| | AT-130
(AT130) Basic information |
| Product Name: | AT-130
(AT130) | | Synonyms: | AT-130
(AT130);AT-130;Benzamide, N-[(1E)-2-bromo-2-(2-methoxyphenyl)-1-(1-piperidinylcarbonyl)ethenyl]-4-nitro-;RNA,HBV,AT-130,Huh-7,DNA/RNA Synthesis,rtM204I,inhibit,rtL180M,AT130,Inhibitor,Hepatitis B virus,HepG2,core;(E)-N-(1-Bromo-1-(2-methoxyphenyl)-3-oxo-3-(piperidin-1-yl)prop-1-en-2-yl)-4-nitrobenzamide;AT-130, 10 mM in DMSO | | CAS: | 211364-06-6 | | MF: | C22H22BrN3O5 | | MW: | 488.33 | | EINECS: | | | Product Categories: | | | Mol File: | 211364-06-6.mol |  |
| | AT-130
(AT130) Chemical Properties |
| Boiling point | 705.2±60.0 °C(Predicted) | | density | 1.459±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 25 mg/mL (51.19 mM) | | form | A solid | | pka | 8.32±0.46(Predicted) | | color | White to off-white |
| | AT-130
(AT130) Usage And Synthesis |
| Uses | AT-130, a phenylpropenamide derivative, is a potent hepatitis B virus (HBV) replication non-nucleoside inhibitor. AT-130 inhibits the viral DNA synthesis with an EC50 of 0.13 μM. AT-130 inhibits both wt and mutant HBVs. AT-130 has anti-HBV activity in hepatoma cells[1][2][3]. | | References | [1] William E Delaney 4th, et al. Phenylpropenamide derivatives AT-61 and AT-130 inhibit replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro. Antimicrob Agents Chemother. 2002 Sep;46(9):3057-60. DOI:10.1128/AAC.46.9.3057-3060.2002
[2] R B Perni , et al. Phenylpropenamide derivatives as inhibitors of hepatitis B virus replication. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2687-90. DOI:10.1016/s0960-894x(00)00544-8
[3] J J Feld, et al. The phenylpropenamide derivative AT-130 blocks HBV replication at the level of viral RNA packaging. Antiviral Res. 2007 Nov;76(2):168-77. DOI:10.1016/j.antiviral.2007.06.014 |
| | AT-130
(AT130) Preparation Products And Raw materials |
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