BIBU1361 dihydrochloride (BIBU 1361 )

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BIBU1361 dihydrochloride (BIBU 1361 ) Suppliers list
Company Name: Beijing Biocreative Technology Co., Ltd.  
Tel: 15522676233
Email: 3007606172@qq.com
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: LGC Science (Shanghai) Ltd.  
Tel: 17717235263 17717235263
Email: offer.de@lgcgroup.com
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

BIBU1361 dihydrochloride (BIBU 1361 ) manufacturers
BIBU1361 dihydrochloride (BIBU 1361 ) Basic information
Product Name:BIBU1361 dihydrochloride (BIBU 1361 )
Synonyms:BIBU1361 dihydrochloride (BIBU 1361 )
CAS:1643609-75-9
MF:C22H28Cl2FN7
MW:480.41
EINECS:
Product Categories:
Mol File:1643609-75-9.mol
BIBU1361 dihydrochloride (BIBU 1361 ) Structure
BIBU1361 dihydrochloride (BIBU 1361 ) Chemical Properties
solubility DMSO:12.92(Max Conc. mg/mL);25.0(Max Conc. mM)
Water:51.69(Max Conc. mg/mL);100.0(Max Conc. mM)
form Solid
color Light Yellow to Dark Orange
Safety Information
MSDS Information
BIBU1361 dihydrochloride (BIBU 1361 ) Usage And Synthesis
DescriptionBIBU-1361 dihydrochloride is an inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that blocks downstream EGFR signaling events such as MAPKK/MAPK activation.
UsesBIBU 1361 Dihydrochloride, is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 3 nM). It also blocks downstream EGFR signaling events such as MAPKK/MAPK activation.
in vitroBIBU (BIBU-1361) caused increased LC3-I to LC3-II conversion and triggered the internalization of EGFR within vacuoles along with its increased co-localization with LC3-II. BIBU caused accumulation of p62 and increased levels of cleaved forms of Beclin-1 in all the cell lines tested._x000D_ _x000D_ Reference: Mol Carcinog. 2013 Dec;52(12):970-82. https://pubmed.ncbi.nlm.nih.gov/22753156/
targetSelective inhibitor of EGFR-kinase.
BIBU1361 dihydrochloride (BIBU 1361 ) Preparation Products And Raw materials
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