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Fmoc-NH-PEG11-CH2CH2COOH manufacturers
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| | Fmoc-NH-PEG11-CH2CH2COOH Basic information |
| Product Name: | Fmoc-NH-PEG11-CH2CH2COOH | | Synonyms: | Fmoc-NH-PEG11-CH2CH2COOH;Fmoc-PEG11-acetic acid;Fmoc-N-Amido-PEG12-CH2COOH;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40-tridecaoxa-4-azadotetracontan-42-oic acid;Fmoc-NH-PEG12-acetic Acid | | CAS: | 2291257-76-4 | | MF: | C41H63NO16 | | MW: | 825.95 | | EINECS: | | | Product Categories: | | | Mol File: | 2291257-76-4.mol |  |
| | Fmoc-NH-PEG11-CH2CH2COOH Chemical Properties |
| Boiling point | 863.2±65.0 °C(Predicted) | | density | 1.182±0.06 g/cm3(Predicted) | | pka | 3.39±0.10(Predicted) | | form | Viscous Liquid | | color | Colorless to light yellow |
| | Fmoc-NH-PEG11-CH2CH2COOH Usage And Synthesis |
| Uses | Fmoc-NH-PEG12-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | Biological Activity | Fmoc-NH-PEG12-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Fmoc-NH-PEG11-CH2CH2COOH Preparation Products And Raw materials |
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