8-M-PDOT

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Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 18930552037
Email: 3bsc@sina.com
Company Name: EMMX Biotechnology LLC  
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Email: info@emmx.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Company Name: BOC Sciences  
Tel: 16314854226; +8616314854226
Email: inquiry@bocsci.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com

8-M-PDOT manufacturers

  • 8-M-PDOT
  • 8-M-PDOT pictures
  • $30.00
  • 2026-05-11
  • CAS:134865-70-6
  • Purity: 99.54%
  • Supply Ability: 10g
  • 8-M-PDOT
  • 8-M-PDOT pictures
  • $30.00
  • 2026-05-11
  • CAS:134865-70-6
  • Purity: 99.54%
  • Supply Ability: 10g
  • 8-M-PDOT
  • 8-M-PDOT pictures
  • $30.00
  • 2025-07-18
  • CAS:134865-70-6
  • Purity: 99.54%
  • Supply Ability: 10g
8-M-PDOT Basic information
Product Name:8-M-PDOT
Synonyms:8-METHOXY-2-PROPIONAMIDOTETRALIN;8-M-PDOT;AH 002;8 M PDOT,8MPDOT;Propanamide, N-(1,2,3,4-tetrahydro-8-methoxy-2-naphthalenyl)-;8-M-PDOT, 10 mM in DMSO
CAS:134865-70-6
MF:C14H19NO2
MW:233.31
EINECS:
Product Categories:
Mol File:134865-70-6.mol
8-M-PDOT Structure
8-M-PDOT Chemical Properties
Boiling point 447.8±45.0 °C(Predicted)
density 1.09±0.1 g/cm3(Predicted)
storage temp. Store at RT
solubility Soluble to 50 mM in ethanol and to 100 mM in DMSO
form Powder
pka15.87±0.20(Predicted)
color White to off-white
Safety Information
MSDS Information
8-M-PDOT Usage And Synthesis
Description8-M-PDOT is a melatonin receptor 2 (MT2) agonist (Ki = 1.12 nM). It is 5.2-fold selective for MT2 over MT1 receptors in a radioligand binding assay. Striatal microinfusion of 8-M-PDOT (10 μg/μl) increases the percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in a rat model of rotenone-induced Parkinson''s disease.
UsesAH 002 is a selective melatonin receptor agonist.
Biological ActivityMelatonin receptor agonist, 20-fold selective for the MT 2 (vs MT 1 ) subtype. At human recombinant MT 1 and MT 2 receptors, displays pK i values of 8.23 and 8.95 respectively.
in vivo

8-M-PDOT (10 μg/μL; administrated into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) treatment shows anxiolytic-like effect[2].

Animal Model:Male Wistar rats (280-320 g) with Rotenone[2]
Dosage:10 μg/μL
Administration:Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes
Result:Increased percentage of time spent in the open arms and in the number of open arms entries.
IC 50MT2
References[1] CHRISTOPHER BROWNING. Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors[J]. British Journal of Pharmacology, 2009, 129 5: 877-886. DOI: 10.1038/sj.bjp.0703130
[2] ANA CAROLINA D. NOSEDA. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects[J]. Sleep Science, 2016, 9 1: Pages 47-54. DOI: 10.1016/j.slsci.2015.10.002
8-M-PDOT Preparation Products And Raw materials
Tag:8-M-PDOT(134865-70-6) Related Product Information
2-Amtt 8-M-PDOT Methoxyphenamine 1-(2-Methoxy-phenyl)-2-butanamine 8-Methoxy-2-aminotetralin VU0155041 sodium salt