2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
生物活性体外研究 用途与合成方法 MSDS 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one价格(试剂级) 上下游产品信息
| 中文名称 | 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one |
|---|---|
| 中文同义词 | 化合物 T26221;SR 13800,MCT1抑制剂;化合物 MCT1-IN-2;7-((3-羟丙基)硫代)-4-异丁基-2-甲基-6-(萘-1-基甲基)-2,6-二氢-1H-吡咯并[3,4-D]哒嗪-1-酮 |
| 英文名称 | 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one |
| 英文同义词 | 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one;SR 13800;MCT1-IN-2;MCT-1-IN-2,MCT1 IN 2,MCT1IN2;1H-Pyrrolo[3,4-d]pyridazin-1-one, 2,6-dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-;MCT1 Inhibitor, SR13800;SR 13800,MCT1 |
| CAS号 | 227321-12-2 |
| 分子式 | C25H29N3O2S |
| 分子量 | 435.58 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 227321-12-2.mol |
| 结构式 | ![2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one 结构式](CAS/20200401/GIF/227321-12-2.gif) |
2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one 性质
| 熔点 | 152 °C |
|---|---|
| 沸点 | 642.8±65.0 °C(Predicted) |
| 密度 | 1.23±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 14.87±0.10(Predicted) |
| 颜色 | 白色至米白色 |
2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one 用途与合成方法
MCT1-IN-2 是有效的单羧酸盐转运蛋白 1 (MCT1) 抑制剂。MCT1-IN-2 具有抗癌活性。
MCT1-IN-2 (compound 3) has a pK
i
of 9.48 for Jurkat T-cells and inhibits human peripheral blood mononuclear cells (PBMC) proliferation (pIC
50
=8.61).
MCT1-IN-2 (compound 1) has an EC
50
of 5.5 nM (MTT assay) and an IC
50
of 105 nM (lactate transport inhibition assay) in human Raji lymphoma cell proliferation.
安全信息
| WGK Germany | WGK 2 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-18974 | 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one MCT1-IN-2 | 227321-12-2 | 1mg | 1900元 |
| 2026/06/05 | HY-18974 | 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one MCT1-IN-2 | 227321-12-2 | 5mg | 4200元 |