RU 28362 manufacturers
- RU28362
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- $2380.00
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2026-05-11
- CAS:74915-64-3
- Purity:
- Supply Ability: 10g
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| | RU 28362 Basic information |
| Product Name: | RU 28362 | | Synonyms: | 11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one;(11β,17β)-11,17-Dihydroxy-6-methyl-17-(1-propynyl)-androsta-1,4,6-trien-3-one;11β,17β-Dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-trien-3-one;Androsta-1,4,6-trien-3-one, 11,17-dihydroxy-6-methyl-17-(1-propynyl)-, (11β,17β)- | | CAS: | 74915-64-3 | | MF: | C23H28O3 | | MW: | 352.47 | | EINECS: | | | Product Categories: | | | Mol File: | 74915-64-3.mol |  |
| | RU 28362 Chemical Properties |
| Boiling point | 533.2±50.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 33 mg/mL, soluble | | form | solid | | pka | 12.82±0.70(Predicted) |
| | RU 28362 Usage And Synthesis |
| Uses | RU28362 is a potent and selective glucocorticoid agonist. RU28362 increases the Bnip3 mRNA levels in neurons. RU28362 inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion[1][2]. RU28362 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | in vivo | RU28362 (150 μg/kg; i.p.) inhibits adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland[2]. | Animal Model: | 250-350 g, adult male Sprague-Dawley rats[2] | | Dosage: | 150 μg/kg | | Administration: | I.p.; 60 min before exposure to a 15-min period of restraint stress | | Result: | Inhibited adrenocorticotrophic hormone (ACTH) and corticosterone secretion and selectively suppressed the stress-induced increase in POMC hnRNA in the anterior pituitary gland. |
| | References | [1] Sandau US, et al. Glucocorticoids exacerbate hypoxia-induced expression of the pro-apoptotic gene Bnip3 in the developing cortex. Neuroscience. 2007 Jan 19;144(2):482-94. DOI:10.1016/j.neuroscience.2006.10.003
[2] Ginsberg AB, et al. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb;18(2):129-38. DOI:10.1111/j.1365-2826.2005.01396.x |
| | RU 28362 Preparation Products And Raw materials |
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