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| | Pressinoic acid Basic information |
| Product Name: | Pressinoic acid | | Synonyms: | H-Cys-Tyr-Phe-Gln-Asn-Cys-OH, (Disulfide bond);L-Cys(1)-L-Tyr-L-Phe-L-Gln-L-Asn-L-Cys(1)-OH;1-6-Oxytocin, 3-L-phenylalanine- (9CI) | | CAS: | 35748-51-7 | | MF: | C33H42N8O10S2 | | MW: | 774.86 | | EINECS: | | | Product Categories: | | | Mol File: | 35748-51-7.mol |  |
| | Pressinoic acid Chemical Properties |
| form | Solid | | Sequence | Cys-Tyr-Phe-Gln-Asn-Cys (Disulfide bridge: Cys1-Cys6) |
| | Pressinoic acid Usage And Synthesis |
| Uses | Pressinoic Acid is a synthetic hexapeptide with potent corticotrophin-releasing activity. Pressinoic Acid is also an oxytocin inhibitor; it induces maternal behavior. | | Enzyme inhibitor | This cyclic hexapeptide (FW = 774.86 g/mol; CAS 35748-51-7) corresponds to the N-terminal six amino acyl residues of vasopressin. If Phe-3 is replaced with Ile, the resulting cyclic hexapeptide, known as tocinoic acid. is identical to the N-terminal six amino acid residues of oxytocin. Pressinoic acid has no known pressor activity, perhaps as result of the loss of the carboxy-terminal tripeptide and/or the incorrect orientation of the Asn-5 side-chain This hexapeptide also activates pineal acetyl-CoA hydrolase and has a potent corticotrophin-releasing activity. Target(s): serotonin N-acetyltransferase. | | References | [1] Saffran M, et al. Pressinoic acid: a peptide with potent corticotrophin-releasing activity. Biochem Biophys Res Commun. 1972 Nov 1;49(3):748-51. DOI:10.1016/0006-291x(72)90474-3
[2] Langs DA, et al. Structure of pressinoic acid: the cyclic moiety of vasopressin. Science. 1986 Jun 6;232(4755):1240-2. DOI:10.1126/science.3704648 |
| | Pressinoic acid Preparation Products And Raw materials |
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