[D- Met2 , Pro5 ]-enkephalinamide

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[D- Met2 , Pro5 ]-enkephalinamide manufacturers
[D- Met2 , Pro5 ]-enkephalinamide Basic information
Product Name:[D- Met2 , Pro5 ]-enkephalinamide
Synonyms:l-tyrosyl-d-methionylglycyl-l-phenylalanyl-l-prolinamid;met(2)-pronh2(5)-enkephali;enkephalin, Met(2)-ProNH2(5)-;d-met(sup2)pro(sup5)-enkephalinamide;gyki14238;L-Prolinamide, L-tyrosyl-D-methionylglycyl-L-phenylalanyl- (9CI)
CAS:63307-63-1
MF:C30H40N6O6S
MW:612.7402
EINECS:
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Mol File:63307-63-1.mol
[D- Met2 , Pro5 ]-enkephalinamide Structure
[D- Met2 , Pro5 ]-enkephalinamide Chemical Properties
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MSDS Information
[D- Met2 , Pro5 ]-enkephalinamide Usage And Synthesis
Uses(D-Met2,Pro5)-Enkephalinamide is a highly potent opiate agonist, and shows antinociceptive activity[1][2][3].
in vivo

(D-Met2,Pro5)-Enkephalinamide (intravenous injection; 0.25 and 0.5 mg/kg; once) leads to the decreasement of prolactin (PRL) secretion in lactating rats[2].

Animal Model:Wistar lactating rats[2]
Dosage:0.25 and 0.5 mg/kg
Administration:Intravenous injection; 0.25 and 0.5 mg/kg; once
Result:Decreased plasma PRL levels 15 min after the administration in continuously lactating rats.
Produced a marked depression in plasma PRL concentration in non-deprived lactating mothers.
References[1] Decsi L, et al. Effect of (D-Met2, Pro5)enkephalinamide, a highly potent opiate agonist, on the drinking behaviour of rats. Neuropharmacology. 1985 Jan;24(1):5-8. DOI:10.1016/0028-3908(85)90087-5
[2] Nagy G, et al. (D-Met2,Pro5) enkephalinamide causes a decrease in plasma prolactin levels of lactating rats continuously suckled and an increase in those deprived of their litter. Regul Pept. 1984 Jul;8(4):321-6. DOI:10.1016/0167-0115(84)90042-9
[3] Wollemann M, et al. Effect of Met-enkephalin and (D-Met2,Pro5)-enkephalinamide on the adenylate cyclase activity of rat brain. Neurochem Res. 1979 Oct;4(5):627-31. DOI:10.1007/BF00964439
[D- Met2 , Pro5 ]-enkephalinamide Preparation Products And Raw materials
Tag:[D- Met2 , Pro5 ]-enkephalinamide(63307-63-1) Related Product Information
[D- Met2 , Pro5 ]-enkephalinamide (D-Met2,Pro5)-enkephalin amide AcOH nifalatide Naloxegol Oxalate Naloxone hydrochloride ENDOMORPHIN-1