c(phg-isoDGR-(NMe)k)

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c(phg-isoDGR-(NMe)k) Basic information

Product Name:	c(phg-isoDGR-(NMe)k)
Synonyms:	c(phg-isoDGR-(NMe)k);Cyclo[L-arginyl-N2-methyl-D-lysyl-(2R)-2-phenylglycyl-L-β-aspartylglycyl];Cyclo(Arg-NMe-DLys-DPhg-β-Asp-Gly);c(phgisoDGR(NMe)k),c(phg isoDGR (NMe)k)
CAS:	1844830-65-4
MF:	C27H41N9O7
MW:	603.68
EINECS:
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Mol File:	1844830-65-4.mol

c(phg-isoDGR-(NMe)k) Chemical Properties

Safety Information

MSDS Information

c(phg-isoDGR-(NMe)k) Usage And Synthesis

Uses	c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM[1].
in vivo	c(phg-isoDGR-(NMe)k) is trimerized with the chelator TRAP and used as a positron-emission tomography tracer for monitoring α5β1 integrin expression in a M21 mouse xenograft^[1].
References	[1] Kapp TG, et al. N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. J Med Chem. 2018 Mar 22;61(6):2490-2499. DOI:10.1021/acs.jmedchem.7b01752

c(phg-isoDGR-(NMe)k) Preparation Products And Raw materials

Tag:c(phg-isoDGR-(NMe)k)(1844830-65-4) Related Product Information

cyclo (Arg-Gly-Asp-d-Phe-Glu)

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