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A2764 dihydrochloride - TRESK inhibitor A2764 manufacturers
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| | A2764 dihydrochloride - TRESK inhibitor A2764 Basic information |
| Product Name: | A2764 dihydrochloride - TRESK inhibitor A2764 | | Synonyms: | A2764 dihydrochloride - TRESK inhibitor A2764;A2764 dihydrochloride;2-((5-Chloroquinolin-8-yl)oxy)-N,N-diethylethanamine dihydrochloride;A2764 diHCl;nociception,A-2764 dihydrochloride,A2764,inhibit,current,A2764 dihydrochloride,KcsA,A-2764,Potassium Channel,migraine,Inhibitor,A 2764,TRESK;A2764 (hydrochloride);A2764 2HCL;A2764 dihydrochloride, 10 mM in DMSO | | CAS: | 861038-72-4 | | MF: | C15H20Cl2N2O | | MW: | 315.24 | | EINECS: | | | Product Categories: | | | Mol File: | 861038-72-4.mol |  |
| | A2764 dihydrochloride - TRESK inhibitor A2764 Chemical Properties |
| Melting point | 184-185 °C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO: 41.67 mg/mL (118.48 mM) | | form | A solid | | color | Light yellow to yellow |
| | A2764 dihydrochloride - TRESK inhibitor A2764 Usage And Synthesis |
| Uses | A2764 dihydrochloride is a highly selective inhibitor of TRESK (TWIK-related spinal cord K+ channel, K2P18.1), which has moderate inhibitory effects on TREK-1 and TALK-1. A2764 dihydrochloride is more sensitive to the activated mTRESK channels (IC50=6.8 μM) than the basal current. A2764 dihydrochloride can lead to cell depolarization and increased excitability in native cells, it has the potential for probing the role of TRESK channel in migraine and nociception[1]. | | References | [1] Lengyel M, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel.Mol Pharmacol. 2019 Jun;95(6):652-660. DOI:10.1124/mol.118.115626 |
| | A2764 dihydrochloride - TRESK inhibitor A2764 Preparation Products And Raw materials |
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