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| | 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Basic information |
| Product Name: | 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride | | Synonyms: | 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride;1-(2-(4-hydroxyphenoxy)ethyl)-4-(4-methylbenzyl)piperidin-4-ol hydrochloride;184833;Co 101244 hydrochloride (also known as PD 174494 and Ro 63-1908);1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-;Inhibitor,Co 101244,Co-101244,Co 101244 hydrochloride,Ionotropic glutamate receptors,inhibit,NR2B,Co101244,PD174494,iGluR,PD 174494,neuroprotective,PD-174494,NMDA;Co 101244 HCl | | CAS: | 193356-17-1 | | MF: | C21H28ClNO3 | | MW: | 377.90492 | | EINECS: | | | Product Categories: | | | Mol File: | 193356-17-1.mol | ![4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Structure](CAS/GIF/193356-17-1.gif) |
| | 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Chemical Properties |
| Melting point | 133-135 °C | | storage temp. | Store at -20°C | | solubility | Soluble to 100 mM in water and to 50 mM in DMSO | | form | Powder | | color | Light yellow to yellow |
| | 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Usage And Synthesis |
| Description | Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50values are 0.043, > 100 and > 100μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effectsin vivoandin vitro. | | Uses | Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1]. | | in vivo | Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit[1]. | | storage | Store at +4°C | | References | [1] Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9. DOI:10.1073/pnas.0903546106 |
| | 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Preparation Products And Raw materials |
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